ESAIC Mentorship Program, BE-1000 Brussels, Belgium.
The European Platform for Research Outcomes after PerIoperative Interventions in Surgery for Cancer Research Group (Euro-Periscope): The Onco-Anaesthesiology Research Group (RG), BE-1000 Brussels, Belgium.
Medicina (Kaunas). 2022 Aug 14;58(8):1102. doi: 10.3390/medicina58081102.
Knowledge shows a divergence of results between preclinical and clinical studies regarding anesthesia and postoperative progression of cancer. While laboratory and animal data from then 2000s onwards raised much enthusiasm in this field of research leading to several clinical investigations worldwide, data from randomized trials seem to have killed off hope for many scientists. However several aspects of the actual knowledge should be reevaluated and there is space for new strategies of investigation. In this paper, we perform a critical review of actual knowledge and propose new research strategies with a special focus on anesthetic management and repurposed anesthetic adjuvants for pancreatic cancer.
知识表明，麻醉和癌症术后进展方面的临床前和临床研究结果存在差异。虽然 21 世纪初以来的实验室和动物数据在该研究领域引起了广泛关注，并导致全球范围内进行了多项临床研究，但随机试验的数据似乎使许多科学家失去了希望。然而，实际知识的几个方面应该重新评估，并且有空间采用新的研究策略。本文对现有知识进行了批判性回顾，并提出了新的研究策略，特别关注胰腺癌的麻醉管理和重新定位的麻醉佐剂。
