慢性中耳炎患者髋部骨折的发生率：真实世界数据。
Incidence of Hip Fractures among Patients with Chronic Otitis Media: The Real-World Data.
机构信息
Department of Otolaryngology Head and Neck Surgery, China Medical University Hospital, Taichung 404327, Taiwan.
Department of Education, China Medical University Hospital, Taichung 404327, Taiwan.
出版信息
Medicina (Kaunas). 2022 Aug 22;58(8):1138. doi: 10.3390/medicina58081138.
Chronic otitis media (COM) has been considered as a localized disease, and its systemic impact is poorly understood. Whether COM-induced inflammation could be associated with systemic bone loss and hip fracture is unknown at present. Our study tried to determine the risk of hip fracture among COM patients. We selected the comparison individuals without the COM coding and paired the controls with COM patients by gender, age, and comorbidities (including osteoporosis) by about a one-to-two ratio. Our study showed that the incidence of hip fracture was 4.48 and 3.92 per 1000 person-years for comparison and COM cohorts respectively. The cumulative incidence of hip fracture is higher in the COM cohort (p < 0.001). After adjustment for gender, age, and comorbidities, the COM patients had a 1.11-fold (aHR = 1.11; 95% CI = 1.05−1.17) risk of hip fracture than the control subjects. Among COM patients, a history of hearing loss is associated with higher (aHR = 1.21; 95% CI = 1.20−1.42) fracture risk. Our study showed that COM patients, especially those with hearing loss, are susceptible to a higher risk for hip fracture.
慢性中耳炎（COM）被认为是一种局限性疾病，其对全身的影响尚未被充分了解。目前尚不清楚 COM 引起的炎症是否与全身骨质流失和髋部骨折有关。我们的研究试图确定 COM 患者发生髋部骨折的风险。我们选择了无 COM 编码的对照个体，并通过性别、年龄和合并症（包括骨质疏松症）将对照组与 COM 患者以大约 1:2 的比例配对。我们的研究表明，对照和 COM 队列的髋部骨折发生率分别为每 1000 人年 4.48 和 3.92 例。COM 队列的累积髋部骨折发生率更高（p<0.001）。在校正性别、年龄和合并症后，COM 患者发生髋部骨折的风险是对照组的 1.11 倍（aHR=1.11；95%CI=1.05−1.17）。在 COM 患者中，听力损失史与更高的骨折风险相关（aHR=1.21；95%CI=1.20−1.42）。我们的研究表明，COM 患者，尤其是有听力损失的患者，髋部骨折的风险更高。
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