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比较采用注射压缩成型和传统注射成型的固体微针的复制保真度。

Comparing the Replication Fidelity of Solid Microneedles Using Injection Compression Moulding and Conventional Injection Moulding.

作者信息

Evens Tim, Castagne Sylvie, Seveno David, Van Bael Albert

机构信息

Department of Materials Engineering Diepenbeek Campus, KU Leuven, Wetenschapspark 27, 3590 Diepenbeek, Belgium.

Department of Mechanical Engineering and Flanders Make@KU Leuven-MaPS, KU Leuven, Celestijnenlaan 300, 3001 Leuven, Belgium.

出版信息

Micromachines (Basel). 2022 Aug 8;13(8):1280. doi: 10.3390/mi13081280.

DOI:10.3390/mi13081280
PMID:36014202
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9415074/
Abstract

Polymer surfaces are increasingly being functionalized with micro- and nano- surface features using mass replication methods such as injection moulding. An example of these are microneedle arrays, which contain needle-like microscopic structures, which facilitate drug or vaccine delivery in a minimally invasive way. In this study, the replication fidelity of two types of solid polycarbonate microneedles was investigated using injection compression moulding and conventional injection moulding. Using a full factorial design of experiments for the injection moulding process, it was found that the volumetric injection rate had the largest positive effect on the replication fidelity. The mould temperature and holding pressure were also found to have a positive effect, while the effect of the melt temperature was found to be insignificant for the considered temperature range. For the injection compression moulding process, it was found that a larger compression stroke resulted in a better replication fidelity. A comparison between the replication fidelity for the injection moulding and injection compression moulding indicated that the injection compression moulding process resulted in a higher and more uniform replication fidelity. Using finite element flow simulations, a higher and more evenly distributed cavity pressure was observed compared to the conventional injection moulding process.

摘要

聚合物表面越来越多地通过注射成型等大规模复制方法，利用微米和纳米表面特征进行功能化处理。其中一个例子是微针阵列，它包含针状微观结构，能够以微创方式促进药物或疫苗的递送。在本研究中，使用注射压缩成型和传统注射成型方法，研究了两种类型的固体聚碳酸酯微针的复制精度。通过对注射成型过程进行全因子实验设计，发现体积注射速率对复制精度有最大的正向影响。还发现模具温度和保压压力有正向影响，而在所考虑的温度范围内，熔体温度的影响不显著。对于注射压缩成型过程，发现较大的压缩行程会带来更好的复制精度。注射成型和注射压缩成型的复制精度比较表明，注射压缩成型过程产生的复制精度更高且更均匀。通过有限元流动模拟，与传统注射成型过程相比，观察到更高且分布更均匀的型腔压力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b305/9415074/05f9d2450e73/micromachines-13-01280-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b305/9415074/e5bfe4cd34e3/micromachines-13-01280-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b305/9415074/c096edd6d3be/micromachines-13-01280-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b305/9415074/c9f5aa32fcca/micromachines-13-01280-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b305/9415074/bc2023865341/micromachines-13-01280-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b305/9415074/7f83b2dccd81/micromachines-13-01280-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b305/9415074/d301afc69977/micromachines-13-01280-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b305/9415074/d17ac402b3e7/micromachines-13-01280-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b305/9415074/3d1de8fc618b/micromachines-13-01280-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b305/9415074/8672c0e4488b/micromachines-13-01280-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b305/9415074/8f22d993f009/micromachines-13-01280-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b305/9415074/d77382db5b26/micromachines-13-01280-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b305/9415074/397432d99763/micromachines-13-01280-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b305/9415074/05f9d2450e73/micromachines-13-01280-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b305/9415074/e5bfe4cd34e3/micromachines-13-01280-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b305/9415074/7202544b4224/micromachines-13-01280-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b305/9415074/7bcbb14669ee/micromachines-13-01280-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b305/9415074/c096edd6d3be/micromachines-13-01280-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b305/9415074/c9f5aa32fcca/micromachines-13-01280-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b305/9415074/bc2023865341/micromachines-13-01280-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b305/9415074/7f83b2dccd81/micromachines-13-01280-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b305/9415074/d301afc69977/micromachines-13-01280-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b305/9415074/d17ac402b3e7/micromachines-13-01280-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b305/9415074/3d1de8fc618b/micromachines-13-01280-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b305/9415074/8672c0e4488b/micromachines-13-01280-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b305/9415074/8f22d993f009/micromachines-13-01280-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b305/9415074/d77382db5b26/micromachines-13-01280-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b305/9415074/397432d99763/micromachines-13-01280-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b305/9415074/05f9d2450e73/micromachines-13-01280-g015.jpg

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本文引用的文献

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Experimental Validation of Injection Molding Simulations of 3D Microparts and Microstructured Components Using Virtual Design of Experiments and Multi-Scale Modeling.使用虚拟实验设计和多尺度建模对3D微零件和微结构部件注塑成型模拟进行实验验证
Micromachines (Basel). 2020 Jun 24;11(6):614. doi: 10.3390/mi11060614.
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Manufacturing Signatures of Injection Molding and Injection Compression Molding for Micro-Structured Polymer Fresnel Lens Production.用于微结构聚合物菲涅耳透镜生产的注塑成型和注射压缩成型的制造特征
Micromachines (Basel). 2018 Dec 10;9(12):653. doi: 10.3390/mi9120653.
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用于高光谱成像的注射压缩成型微透镜阵列
Micromachines (Basel). 2018 Jul 18;9(7):355. doi: 10.3390/mi9070355.
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Nanopattern insert molding.纳米图案插入成型。
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