Nair Karthik, Whiteside Benjamin, Grant Colin, Patel Rajnikant, Tuinea-Bobe Cristina, Norris Keith, Paradkar Anant
Centre for Polymer Micro and Nano technology, Interdisciplinary Research Centre, School of Engineering and Informatics, University of Bradford, Bradford, BD7 1DP, UK.
Centre for Pharmaceutical Engineering Science, School of pharmacy, University of Bradford, Bradford, BD7 1DP, UK.
Pharmaceutics. 2015 Oct 30;7(4):471-85. doi: 10.3390/pharmaceutics7040471.
Plasma technology has been widely used to increase the surface energy of the polymer surfaces for many industrial applications; in particular to increase in wettability. The present work was carried out to investigate how surface modification using plasma treatment modifies the surface energy of micro-injection moulded microneedles and its influence on drug delivery. Microneedles of polyether ether ketone and polycarbonate and have been manufactured using micro-injection moulding and samples from each production batch have been subsequently subjected to a range of plasma treatment. These samples were coated with bovine serum albumin to study the protein adsorption on these treated polymer surfaces. Sample surfaces structures, before and after treatment, were studied using atomic force microscope and surface energies have been obtained using contact angle measurement and calculated using the Owens-Wendt theory. Adsorption performance of bovine serum albumin and release kinetics for each sample set was assessed using a Franz diffusion cell. Results indicate that plasma treatment significantly increases the surface energy and roughness of the microneedles resulting in better adsorption and release of BSA.
等离子体技术已被广泛应用于许多工业应用中，以提高聚合物表面的表面能，特别是提高润湿性。目前的工作是为了研究使用等离子体处理进行表面改性如何改变微注塑成型微针的表面能及其对药物递送的影响。聚醚醚酮和聚碳酸酯微针已通过微注塑成型制造，并且随后对每个生产批次的样品进行了一系列等离子体处理。这些样品用牛血清白蛋白包被，以研究蛋白质在这些经处理的聚合物表面上的吸附。使用原子力显微镜研究了处理前后样品的表面结构，并使用接触角测量获得表面能，并根据欧文斯 - 温特理论进行计算。使用弗兰兹扩散池评估每组样品中牛血清白蛋白的吸附性能和释放动力学。结果表明，等离子体处理显著提高了微针的表面能和粗糙度，从而导致牛血清白蛋白的更好吸附和释放。
