Hangzhou Occupational Disease Prevention and Treatment Hospital, Hangzhou 310014, China.
Molecules. 2022 Aug 16;27(16):5211. doi: 10.3390/molecules27165211.
The abuse of buprenorphine and methadone has grown into a rising worldwide issue. After their consumption, buprenorphine, methadone and their metabolites can be found in the human organism. Due to the difficulty in the assessment of these compounds by routine drug screening, the importance of developing highly sensitive analytical approaches is undeniable. Liquid chromatography tandem mass spectrometry is the preferable technique for the determination of buprenorphine, methadone and their metabolites in biological matrices including urine, plasma, nails or oral fluids. This research aims to review a critical discussion of the latest trends for the monitoring of buprenorphine, methadone and their metabolites in various biological specimens.
丁丙诺啡和美沙酮的滥用已成为全球日益严重的问题。丁丙诺啡、美沙酮及其代谢物在人体中均可被检测到。由于常规药物筛选方法难以评估这些化合物，因此开发高灵敏度分析方法的重要性是不可否认的。液相色谱串联质谱法是检测尿液、血浆、指甲或唾液等生物基质中丁丙诺啡、美沙酮及其代谢物的首选技术。本研究旨在对丁丙诺啡、美沙酮及其代谢物在各种生物标本中的监测的最新趋势进行批判性讨论。
