Akbari Sedigheh, Jahani Shohreh, Foroughi Mohammad Mehdi, Hassani Nadiki Hadi
Department of Chemistry, Islamic Azad University Kerman Branch Kerman Iran
Noncommunicable Diseases Research Center, Bam University of Medical Sciences Bam Iran.
RSC Adv. 2020 Oct 19;10(63):38532-38545. doi: 10.1039/d0ra06480g. eCollection 2020 Oct 15.
The present research synthesized manganese dioxide nano-flowers (β-MnO-NF) a simplified technique for electro-catalytic utilization. Moreover, morphological characteristics and X-ray analyses showed Mn in the oxide form with β-type crystallographic structure. In addition, the research proposed a new efficient electro-chemical sensor to detect methadone at the modified glassy carbon electrode (β-MnO-NF/GCE). It has been found that oxidizing methadone is irreversible and shows a diffusion controlled procedure at the β-MnO-NF/GCE. Moreover, β-MnO-NF/GCE was considerably enhanced in the anodic peak current of methadone related to the separation of morphine and methadone overlapping voltammetric responses with probable difference of 510 mV. In addition, a linear increase has been observed between the catalytic peak currents gained by the differential pulse voltammetry (DPV) of morphine and methadone and their concentrations in the range between 0.1-200.0 μM and 0.1-250.0 μM, respectively. Furthermore, the limits of detection (LOD) for methadone and morphine were found to be 5.6 nM and 8.3 nM, respectively. It has been found that our electrode could have a successful application for detecting methadone and morphine in the drug dose form, urine, and saliva samples. Thus, this condition demonstrated that β-MnO-NF/GCE displays good analytical performances for the detection of methadone.
本研究合成了二氧化锰纳米花（β-MnO-NF），这是一种用于电催化利用的简化技术。此外，形态特征和X射线分析表明，锰以β型晶体结构的氧化物形式存在。此外，该研究提出了一种新型高效电化学传感器，用于在修饰玻碳电极（β-MnO-NF/GCE）上检测美沙酮。研究发现，美沙酮的氧化是不可逆的，并且在β-MnO-NF/GCE上显示出扩散控制过程。此外，与吗啡和美沙酮重叠伏安响应的分离相关，β-MnO-NF/GCE上美沙酮的阳极峰值电流显著增强，可能的差异为510 mV。此外，通过差分脉冲伏安法（DPV）获得的吗啡和美沙酮的催化峰值电流与其浓度之间分别在0.1 - 200.0 μM和0.1 - 250.0 μM范围内呈线性增加。此外，美沙酮和吗啡的检测限（LOD）分别为5.6 nM和8.3 nM。研究发现，我们的电极可成功应用于检测药物剂型、尿液和唾液样本中的美沙酮和吗啡。因此，这种情况表明β-MnO-NF/GCE在美沙酮检测方面具有良好的分析性能。
