Centre for Nano and Material Sciences, Jain University, Jain Global Campus, Bangalore 562112, India.
Organic Chemistry Section, Chemical Sciences & Technology Division, National Institute for Interdisciplinary Science and Technology (CSIR), Thiruvananthapuram 695019, India.
Molecules. 2022 Aug 16;27(16):5220. doi: 10.3390/molecules27165220.
Coumarins are fused six-membered oxygen-containing benzoheterocycles that join two synthetically useful rings: α-pyrone and benzene. A survey of the literature shows that coumarins and their metal complexes have received great interest from synthetic chemists, medicinal scientists, and pharmacists due to their wide spectrum of biological applications. For instance, coumarin and its derivatives have been used as precursors to prepare a large variety of medicinal agents. Likewise, coumarin-derived imine-metal complexes have been found to display a variety of therapeutic applications, such as antibacterial, antifungal, anticancer, antioxidant, anthelmintic, pesticidal, and nematocidal activities. This review highlights the current synthetic methodologies and known bioactivities of coumarin-derived imine-metal complexes that make this molecule a more attractive scaffold for the discovery of newer drugs.
香豆素是一种稠合的六元含氧苯并杂环，由两个合成有用的环：α-吡喃酮和苯组成。文献综述表明，由于香豆素及其金属配合物具有广泛的生物应用，因此受到合成化学家、药物科学家和药剂师的极大关注。例如，香豆素及其衍生物已被用作制备各种药物的前体。同样，发现香豆素衍生的亚胺-金属配合物具有多种治疗应用，如抗菌、抗真菌、抗癌、抗氧化、驱虫、杀虫和杀线虫活性。本综述重点介绍了香豆素衍生的亚胺-金属配合物的当前合成方法和已知的生物活性，这使得该分子成为发现新型药物更有吸引力的支架。
