College of Materials Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, China.
School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Molecules. 2022 Aug 19;27(16):5301. doi: 10.3390/molecules27165301.
Bl. is a traditional Chinese materia medica widely used to treat several diseases. Chemical and pharmacological studies on have been carried out; however, neither of them has been fully explored. In this study, an array of compounds was isolated from the title plant, including a new anthraquinone, ophiorrhizaquinone A (), three alkaloids - and seven other compounds - with diverse structural types. Additionally, compounds , , , , and were isolated from the genus of for the first time. Antioxidant bioassays in vitro using DPPH and ABTS were performed, and the results showed that compound exhibited modest antioxidant activity with IC values of 0.0321 mg/mL and 0.0319 mg/mL, respectively. An in silico study of PPARα agonistic activities of compounds and was conducted by molecular docking experiments, revealing that both of them occupied the active site of PPARα via hydrogen bonds and hydrophobic interactions effectively. This study enriched both the phytochemical and pharmacological profiles of .
荛花是一种传统的中国药材，广泛用于治疗多种疾病。已经对荛花进行了化学和药理学研究；然而，它们都没有得到充分的探索。在这项研究中，从该植物中分离出了一系列化合物，包括一种新的蒽醌类化合物，ophiorrhizaquinone A（），三种生物碱——和另外七种具有不同结构类型的化合物。此外，化合物、、、、、和从属中首次分离出来。采用 DPPH 和 ABTS 进行了体外抗氧化生物测定，结果表明化合物具有适度的抗氧化活性，IC 值分别为 0.0321mg/mL 和 0.0319mg/mL。通过分子对接实验对化合物和的 PPARα 激动活性进行了计算机模拟研究，表明它们都通过氢键和疏水相互作用有效地占据了 PPARα 的活性部位。这项研究丰富了荛花的植物化学和药理学特征。
