用于PET/MR成像的无螯合剂64铜掺入氧化铁纳米颗粒：提高放射性铜稳定性和细胞活力

Chelator-Free Copper-64-Incorporated Iron Oxide Nanoparticles for PET/MR Imaging: Improved Radiocopper Stability and Cell Viability.

作者信息

Jang Hye Min, Jung Myung Hwan, Lee Jae Sang, Lee Jun Sig, Lim In-Cheol, Im Hyunsik, Kim Sang Wook, Kang Sung-A, Cho Won-Je, Park Jun Kue

机构信息

Korea Multi-Purpose Accelerator Complex, Korea Atomic Energy Research Institute, 181 Mirae-ro, Gyeongju 38180, Korea.

Division of Physics and Semiconductor Science, Dongguk University, Seoul 04620, Korea.

出版信息

Nanomaterials (Basel). 2022 Aug 14;12(16):2791. doi: 10.3390/nano12162791.

We have developed chelator-free copper-64-incorporated iron oxide (IO) nanoparticle (NPs) which have both magnetic and radioactive properties being applied to positron emission tomography (PET)-magnetic resonance imaging (MRI). We have found that the IO nanoparticles composed of radioactive isotope Cu may act as a contrast agent being a diagnostic tool for PET as well as a good MRI nanoprobe due to their good / ratio. Furthermore, we demonstrate that the Cu incorporation at the core of core-shell-structured IO NPs exhibits a good in vivo stability, giving us an insightful strategy for the design of a contrast agent for the PET-MRI system.