Department of Product Development, Pigeon Corporation, Ibaraki 300-2495, Japan.
Department of Corporate Communications, Pigeon Corporation, Tokyo 103-8480, Japan.
Nutrients. 2022 Aug 9;14(16):3255. doi: 10.3390/nu14163255.
Colostrum is the first food for newborns and it contains various crucial immune factors. The concentrations of immune factors in breast milk may change depending on maternal characteristics such as body mass index, collection day, and age at first pregnancy. In this exploratory study, we investigated the association between TGF-β1, TGF-β2, and IgA in colostrum and rarely studied factors that affect breast milk components, including the use of labor-inducing medication, colostrum secretion, sex of newborns, breast or nipple problems, and nipple care. Breast milk samples were collected from 42 mothers and analyzed for TGF-β1, TGF-β2, and IgA. The results suggest that parity and mode of delivery may be correlated with the concentrations of immune factors in colostrum. However, we found no association between the immune factors in colostrum and the use of labor-inducing medications, colostrum secretion, sex of newborns, breast or nipple problems, and nipple care. These findings have some implications for further analysis of the effects of immune factors in breast milk on the prognosis of allergies in children.
初乳是新生儿的第一食物，其中含有各种关键的免疫因子。母乳中的免疫因子浓度可能会因产妇的身体质量指数、采集日期和初次妊娠年龄等特征而有所不同。在这项探索性研究中，我们调查了初乳中 TGF-β1、TGF-β2 和 IgA 与影响母乳成分的罕见因素之间的关系，这些因素包括催产药物的使用、初乳分泌、新生儿性别、乳房或乳头问题以及乳头护理。我们从 42 位母亲那里采集了母乳样本，并对 TGF-β1、TGF-β2 和 IgA 进行了分析。结果表明，产次和分娩方式可能与初乳中免疫因子的浓度有关。然而，我们并未发现初乳中的免疫因子与催产药物的使用、初乳分泌、新生儿性别、乳房或乳头问题以及乳头护理之间存在关联。这些发现对进一步分析母乳中免疫因子对儿童过敏预后的影响具有一定意义。
