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辅酶 Q10 在预防砷处理的 CHO-K1 细胞氧化应激中的抗氧化作用及锌作为促氧化剂的可能参与。

Antioxidant Effect of Coenzyme Q10 in the Prevention of Oxidative Stress in Arsenic-Treated CHO-K1 Cells and Possible Participation of Zinc as a Pro-Oxidant Agent.

机构信息

Post-Graduation Program in Pharmaceutical Sciences, Multidisciplinary Research Laboratory, Department of Clinical and Toxicological Analysis (DACT), Health Sciences Center, Federal University of the Rio Grande do Norte (UFRN), Natal 59012570, Brazil.

Institute of Research and Development in Process Engineering, Biotechnology and Alternative Energies (PROBIEN), National Council for Scientific and Technical Research (CONICET), School of Agricultural Sciences, Neuquén 8300, Argentina.

出版信息

Nutrients. 2022 Aug 10;14(16):3265. doi: 10.3390/nu14163265.

DOI:10.3390/nu14163265
PMID:36014770
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9412518/
Abstract

Oxidative stress is an imbalance between levels of reactive oxygen species (ROS) and antioxidant enzymes. Compounds with antioxidant properties, such as coenzyme Q10 (CoQ10), can reduce cellular imbalance caused by an increase in ROS. CoQ10 participates in modulating redox homeostasis due to its antioxidant activity and its preserving mitochondrial functions. Thus, the present study demonstrated the protective effects of CoQ10 against oxidative stress and cytotoxicity induced by arsenic (As). Antioxidant capacity, formation of hydroperoxides, generation of ROS, and the effect on cellular viability of CoQ10, were investigated to determine the protective effect of CoQ10 against As and pro-oxidant compounds, such as zinc. Cell viability assays showed that CoQ10 is cytoprotective under cellular stress conditions, with potent antioxidant activity, regardless of the concentration tested. Zn, when used at higher concentrations, can increase ROS and show a pro-oxidant effect causing cell damage. The cytotoxic effect observed for As, Zn, or the combination of both could be prevented by CoQ10, without any decrease in its activity at cellular levels when combined with Zn.

摘要

氧化应激是活性氧（ROS）和抗氧化酶水平之间的失衡。具有抗氧化特性的化合物，如辅酶 Q10（CoQ10），可以减少因 ROS 增加而引起的细胞失衡。由于其抗氧化活性及其对线粒体功能的保护作用，CoQ10 参与调节氧化还原稳态。因此，本研究证明了 CoQ10 对砷（As）诱导的氧化应激和细胞毒性的保护作用。为了确定 CoQ10 对 As 和促氧化剂化合物（如锌）的保护作用，研究了 CoQ10 的抗氧化能力、氢过氧化物的形成、ROS 的产生以及对细胞活力的影响。细胞活力测定表明，CoQ10 在细胞应激条件下具有细胞保护作用，具有很强的抗氧化活性，无论测试浓度如何。当使用较高浓度的 Zn 时，它会增加 ROS 并显示出促氧化作用，导致细胞损伤。CoQ10 可以预防观察到的 As、Zn 或两者的组合的细胞毒性作用，而当其与 Zn 结合时，其在细胞水平上的活性没有任何降低。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/791b/9412518/17cad672b16d/nutrients-14-03265-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/791b/9412518/05c70ce9a712/nutrients-14-03265-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/791b/9412518/8a7d586ad627/nutrients-14-03265-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/791b/9412518/e60400bac19a/nutrients-14-03265-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/791b/9412518/7b152d93b3ba/nutrients-14-03265-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/791b/9412518/69e1f753155c/nutrients-14-03265-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/791b/9412518/d8b18c376314/nutrients-14-03265-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/791b/9412518/1b198237733b/nutrients-14-03265-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/791b/9412518/17cad672b16d/nutrients-14-03265-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/791b/9412518/05c70ce9a712/nutrients-14-03265-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/791b/9412518/8a7d586ad627/nutrients-14-03265-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/791b/9412518/e60400bac19a/nutrients-14-03265-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/791b/9412518/7b152d93b3ba/nutrients-14-03265-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/791b/9412518/69e1f753155c/nutrients-14-03265-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/791b/9412518/d8b18c376314/nutrients-14-03265-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/791b/9412518/1b198237733b/nutrients-14-03265-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/791b/9412518/17cad672b16d/nutrients-14-03265-g008.jpg

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本文引用的文献

[1]
The effects of coenzyme Q supplement on blood lipid indices and hepatic antioxidant defense system in SD rats fed a high cholesterol diet.

Lab Anim Res. 2019-8-8

[2]
Coenzyme Q10 Activates the Antioxidant Machinery and Inhibits the Inflammatory and Apoptotic Cascades Against Lead Acetate-Induced Renal Injury in Rats.

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Anti-IIa activity and antitumor properties of a hybrid heparin/heparan sulfate-like compound from Litopenaeus vannamei shrimp.

Int J Biol Macromol. 2018-6-30

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