年龄相关性黄斑变性与阿尔茨海默病之间缺乏双向关联：一项孟德尔随机化研究。
Lack of bidirectional association between age-related macular degeneration and Alzheimer's disease: A Mendelian randomization study.
机构信息
Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, China.
出版信息
Alzheimers Dement. 2022 Dec;18(12):2725-2729. doi: 10.1002/alz.12775. Epub 2022 Aug 25.
INTRODUCTION
Observational studies have reported inconsistent results on the relationship between age-related macular degeneration (AMD) and Alzheimer's disease (AD). Therefore, we aimed to determine whether there is a causal association between AMD and AD.
METHODS
This two-sample bidirectional Mendelian randomization (MR) study evaluated causal associations between advanced AMD and AD using summary data from large genome-wide association studies.
RESULTS
Genetic liability for advanced AMD showed no statistical causal association with AD risk (odds ratio [OR] = 0.999, 95% confidence interval [CI]: 0.955-1.044, P = .948). Reverse MR analysis provided little support for a causal effect of AD on advanced AMD (OR = 0.973, 95%CI: 0.938-1.008, P = .133).
DISCUSSION
This MR study found no evidence to support a bidirectional causality between advanced AMD and AD.
HIGHLIGHTS
We evaluated the bidirectional causal relationship between advanced AMD and AD. Advanced AMD showed no statistical causal association with risk of AD. We found no evidence to support a causal effect of AD on advanced AMD risk. The associations observed in epidemiological studies should not be considered causal.
简介
观察性研究报告称，年龄相关性黄斑变性（AMD）和阿尔茨海默病（AD）之间的关系存在不一致的结果。因此，我们旨在确定 AMD 和 AD 之间是否存在因果关系。
方法
本两样本双向孟德尔随机化（MR）研究使用来自大型全基因组关联研究的汇总数据，评估了晚期 AMD 和 AD 之间的因果关系。
结果
晚期 AMD 的遗传易感性与 AD 风险之间没有统计学上的因果关联（比值比 [OR] = 0.999，95%置信区间 [CI]：0.955-1.044，P =.948）。反向 MR 分析几乎没有支持 AD 对晚期 AMD 有因果影响（OR = 0.973，95%CI：0.938-1.008，P =.133）。
讨论
本 MR 研究没有发现晚期 AMD 和 AD 之间存在双向因果关系的证据。
重点
我们评估了晚期 AMD 和 AD 之间的双向因果关系。晚期 AMD 与 AD 风险之间没有统计学上的因果关联。我们没有发现 AD 对晚期 AMD 风险有因果影响的证据。流行病学研究中观察到的关联不应被视为因果关系。
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