Xu Xinmin, Li Angcheng, Xu Xia, Gong Qiangjun, Zhu Shengjie, Chu Wenya, Ding Shubo
Department of Radiotherapy, Jinhua Municipal Central Hospital, Jinhua, China.
Front Neurol. 2022 Aug 9;13:964856. doi: 10.3389/fneur.2022.964856. eCollection 2022.
Ependymoblastoma is a rare embryonal neoplasm of the nervous system, and the entity is even rare with distant metastasis. This case can help refine the existing literature and provide lessons for the management of other patients with ependymoblastoma. The present case concerns an adolescent with supratentorial ependymoblastoma, who received gross-total resection (GTR), postoperative radiotherapy, and six cycles of chemotherapy, with disease-free survival (DFS) of about 5.3 years. Subsequently, pulmonary metastasis occurred, but no intracranial lesion was found. Finally, combined treatment with radiotherapy and chemotherapy significantly reduced the lung lesions, with progression-free survival (PFS) of 10 months and long-term survival of 6.3 years. This case indicates that the lung metastases of ependymoblastoma are relatively sensitive to radiation, but lung metastases have not completely disappeared. Perhaps, increasing the radiation dose to lung metastases can improve the efficacy, which is worth exploring.
室管膜母细胞瘤是一种罕见的神经系统胚胎性肿瘤，而发生远处转移的情况更为罕见。该病例有助于完善现有文献，并为其他室管膜母细胞瘤患者的治疗提供经验教训。本病例为一名患有幕上室管膜母细胞瘤的青少年，接受了全切除（GTR）、术后放疗和六个周期的化疗，无病生存期（DFS）约为5.3年。随后发生了肺转移，但未发现颅内病变。最后，放疗和化疗联合治疗显著缩小了肺部病变，无进展生存期（PFS）为10个月，长期生存期为6.3年。该病例表明，室管膜母细胞瘤的肺转移对放疗相对敏感，但肺转移灶并未完全消失。或许，增加对肺转移灶的放疗剂量可以提高疗效，这值得探索。
