Aksoy M, Berger M R, Schmähl D
Nutr Cancer. 1987;9(4):227-35. doi: 10.1080/01635588709513931.
This study describes the influence of isocalorically fed diets (containing different amounts of fat) on tumor incidence and parameters of fat metabolism in female Sprague-Dawley rats. Comparisons are made between rats induced with methylnitrosourea (25 mg/kg body wt) and untreated controls (Group I). The animals received either control diets (3.9% fat by weight, Groups I and II) or fat-enriched diets (10.7%, Group III; 15.6%, Group IV; 21.4%, Group V) over a period of 180 days. At the termination of the experiment, intake of the diet containing 10.7% fat by weight (24% fat per total calories) was associated with the highest tumor incidence. Comparing the different diets, liver lipid concentrations in the individual groups increased with increasing dietary fat, whereas the total lipid in plasma decreased. During the feeding period, total lipid of the liver and plasma, and plasma cholesterol, increased in all groups, but triglycerides of plasma decreased. However, when plasma cholesterol and triglycerides were calculated as a relative amount of total lipid in plasma, cholesterol was found to be significantly decreased in Groups III and IV, and triglycerides were increased in Group III but decreased significantly in Groups I, II, and V at the end of the experiment.
本研究描述了等热量喂养的饮食（含有不同量的脂肪）对雌性斯普拉格-道利大鼠肿瘤发生率和脂肪代谢参数的影响。对用甲基亚硝基脲（25毫克/千克体重）诱导的大鼠和未处理的对照组（第一组）进行了比较。在180天的时间里，动物们分别接受对照饮食（按重量计含3.9%脂肪，第一组和第二组）或高脂肪饮食（10.7%，第三组；15.6%，第四组；21.4%，第五组）。在实验结束时，摄入按重量计含10.7%脂肪（占总热量的24%）的饮食与最高的肿瘤发生率相关。比较不同的饮食，各小组肝脏脂质浓度随着饮食脂肪含量的增加而增加，而血浆中的总脂质则减少。在喂养期间，所有组的肝脏和血浆总脂质以及血浆胆固醇均增加，但血浆甘油三酯减少。然而，当以血浆总脂质的相对量来计算血浆胆固醇和甘油三酯时，发现第三组和第四组的胆固醇显著降低，第三组的甘油三酯增加，但在实验结束时，第一组、第二组和第五组的甘油三酯显著降低。
