Cohen L A, Chan P C
Nutr Cancer. 1982;4(2):99-106. doi: 10.1080/01635588209513745.
The effect of high- and low-fat diets, with and without cholesterol supplementation, on the development of N-methylnitrosourea (NMU)-induced mammary tumors was assessed. Diets consisting of 1. high fat (HF) (20% lard), 2. HF + cholesterol, 3. low fat (LF) (4% lard) + cholesterol, and 4. LF were fed to F344 female rats (24 animals/group) 2 days after NMU administration, and cumulative mammary tumor incidence was monitored for a total of 26 weeks. Animals fed HF diets exhibited significantly greater tumor incidences and numbers of tumors/animal than did animals fed LF diets (p less than .0001), regardless of whether cholesterol was present in the diet. These results are consistent with the hypothesis that the mammary-tumor promoting effects of HF diets are exerted primarily by the triglyceride fraction rather than by the nonsaponifiable (sterol) fraction of total dietary fat.
评估了高脂和低脂饮食（添加或不添加胆固醇）对N-甲基亚硝基脲（NMU）诱导的乳腺肿瘤发生发展的影响。在给予NMU后2天，将由以下组成的饮食喂给F344雌性大鼠（每组24只动物）：1. 高脂肪（HF）（20%猪油），2. HF + 胆固醇，3. 低脂肪（LF）（4%猪油） + 胆固醇，4. LF，并总共监测26周的累积乳腺肿瘤发生率。无论饮食中是否存在胆固醇，喂食HF饮食的动物比喂食LF饮食的动物表现出明显更高的肿瘤发生率和每只动物的肿瘤数量（p <.0001）。这些结果与以下假设一致，即HF饮食的乳腺肿瘤促进作用主要由甘油三酯部分而非总膳食脂肪的不可皂化（甾醇）部分发挥。
