Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
NHC Key Laboratory of Reproductive Health Engineering Technology Research (NRIFP), National Research Institute for Family Planning, Beijing 100081, China.
Oxid Med Cell Longev. 2022 Aug 16;2022:3425877. doi: 10.1155/2022/3425877. eCollection 2022.
Premature ovarian insufficiency (POI) is a female reproductive disorder of unknown etiology with no definite pathogenesis. Melatonin (MT) is an endogenous hormone synthesized mainly by pineal cells and has strong endogenous effects in regulating ovarian function. To systematically explore the pharmacological mechanism of MT on POI therapy, a literature review approach was conducted at the signaling pathways level.
Relevant literatures were searched and downloaded from databases, including PubMed and China National Knowledge Infrastructure, using the keywords "premature ovarian insufficiency," "Hippo signaling pathways," and "melatonin." The search criteria were from 2010 to 2022. Text mining was also performed.
MT is involved in the regulation of Hippo signaling pathway in a variety of modes and has been correlated with ovarian function.
The purpose of this review is to summarize the research progress of Hippo signaling pathways and significance of MT in POI, the potential crosstalk between MT and Hippo signaling pathways, and the prospective therapy.
卵巢早衰（POI）是一种病因不明的女性生殖系统疾病，其发病机制尚不清楚。褪黑素（MT）是一种主要由松果体细胞合成的内源性激素，在调节卵巢功能方面具有很强的内源性作用。为了系统地探讨 MT 治疗 POI 的药理学机制，我们在信号通路水平上进行了文献回顾。
我们使用关键词“卵巢早衰”、“Hippo 信号通路”和“褪黑素”，从 PubMed 和中国知网等数据库中搜索并下载了相关文献，检索时间为 2010 年至 2022 年。我们还进行了文本挖掘。
MT 以多种模式参与 Hippo 信号通路的调节，并与卵巢功能相关。
本综述的目的是总结 Hippo 信号通路和 MT 在 POI 中的作用及其潜在的相互作用，以及 MT 在 POI 治疗中的应用前景。
