Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Immunology Research Center, Tabriz University of Medical Sciences, PO. Box: 51376563833, Tabriz, Iran.
Mol Cell Biochem. 2021 Aug;476(8):3177-3190. doi: 10.1007/s11010-021-04151-z. Epub 2021 Apr 17.
Melatonin (N-acetyl-5-methoxytryptamine), the main product of pineal gland in vertebrates, is well known for its multifunctional role which has great influences on the reproductive system. Recent studies documented that melatonin is a powerful free radical scavenger that affects the reproductive system function and female infertility by MT1 and MT2 receptors. Furthermore, cancer researches indicate the influence of melatonin on the modulation of tumor cell signaling pathways resulting in growth inhibitor of the both in vivo/in vitro models. Cancer adjuvant therapy can also benefit from melatonin through therapeutic impact and decreasing the side effects of radiation and chemotherapy. This article reviews the scientific evidence about the influence of melatonin and its mechanism of action on the fertility potential, physiological alteration, and anticancer efficacy, during experimental and clinical studies.
褪黑素（N-乙酰-5-甲氧基色胺），脊椎动物的松果体的主要产物，以其对生殖系统的多功能作用而闻名。最近的研究表明，褪黑素是一种强大的自由基清除剂，通过 MT1 和 MT2 受体影响生殖系统功能和女性不孕。此外，癌症研究表明，褪黑素对肿瘤细胞信号通路的调节会导致体内/体外模型中肿瘤细胞的生长抑制。癌症辅助治疗也可以通过治疗作用和减少放疗和化疗的副作用而受益于褪黑素。本文综述了关于褪黑素及其对生育潜力、生理变化和抗癌疗效的作用机制的科学证据，这些证据来自于实验和临床研究。
