Wusiman Wugelanmu, Zhang Zerui, Ding Qiang, Liu Mei
Department of Gastroenterology, Institute of Liver and Gastrointestinal Diseases, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Front Physiol. 2022 Aug 9;13:935576. doi: 10.3389/fphys.2022.935576. eCollection 2022.
Aminoacyl-tRNA synthetases (ARSs) catalyze the ligation of amino acids to their cognate transfer RNAs and are indispensable enzymes for protein biosynthesis in all the cells. Previously, ARSs were considered simply as housekeeping enzymes, however, they are now known to be involved in a variety of physiological and pathological processes, such as tumorigenesis, angiogenesis, and immune response. In this review, we summarize the role of ARSs in the digestive system, including the esophagus, stomach, small intestine, colon, as well as the auxiliary organs such as the pancreas, liver, and the gallbladder. Furthermore, we specifically focus on the diagnostic and prognostic value of ARSs in cancers, aiming to provide new insights into the pathophysiological implications of ARSs in tumorigenesis.
氨酰-tRNA合成酶（ARSs）催化氨基酸与其对应的转运RNA连接，是所有细胞中蛋白质生物合成所必需的酶。以前，ARSs仅仅被视为管家酶，然而，现在已知它们参与多种生理和病理过程，如肿瘤发生、血管生成和免疫反应。在本综述中，我们总结了ARSs在消化系统中的作用，包括食管、胃、小肠、结肠，以及胰腺、肝脏和胆囊等附属器官。此外，我们特别关注ARSs在癌症中的诊断和预后价值，旨在为ARSs在肿瘤发生中的病理生理意义提供新的见解。
