寨卡病毒感染会导致成年小鼠出现性别特异性记忆缺陷和神经改变。
Exposure to Zika Virus Results in sex-Specific Memory Deficits and Neurological Alterations in Adult Mice.
机构信息
Department of Biochemistry and Immunology, ICB, 28114Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil.
Department of Microbiology, ICB, 28114Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil.
出版信息
ASN Neuro. 2022 Jan-Dec;14:17590914221121257. doi: 10.1177/17590914221121257.
Abstract
exposure to ZIKV leads to decreased number of neurons in adult mice. Female mice exposed to ZIKV exhibit lower levels of BDNF, a decrease in synaptic markers, memory deficits, and risk-taking behavior during adulthood.
摘要
寨卡病毒（ZIKV）暴露导致成年小鼠神经元数量减少。感染寨卡病毒的雌性小鼠表现出脑源性神经营养因子（BDNF）水平降低、突触标志物减少、成年期记忆缺陷和冒险行为增加。
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