Department of Anesthesiology, University of Tennessee Medical Center, Knoxville, TN 37920, USA.
Department of Public Health, University of Tennessee at Knoxville, Knoxville, TN 37996, USA.
Pain Manag. 2022 Oct;12(7):821-827. doi: 10.2217/pmt-2021-0126. Epub 2022 Aug 26.
At our institution, reductions to hydromorphone and fentanyl unit dose quantities provided us with a unique opportunity to study opioid utilization. A retrospective study examining effects of changes in opioid unit dose on intra-operative and postoperative opioid utilization in patients who underwent laparoscopic cholecystectomy. The study included three arms: the predosage change (n = 254), fentanyl only change group (n = 102) and the postdosage change arm (n = 254). Decreasing opioid unit dosing decreased intraoperative opioid administration and total perioperative utilization. Decreased postanesthesia care unit morphine milligram equivalent (MME) requirements were observed in all, but one group comparison. Our data suggests that opioid unit dosing and administration are directly proportional and that decreased intraoperative MME utilization leads to decreased total perioperative MME use.
在我们的机构中，氢吗啡酮和芬太尼单位剂量的减少为我们提供了一个独特的机会来研究阿片类药物的使用情况。这项回顾性研究考察了改变阿片类药物单位剂量对接受腹腔镜胆囊切除术患者术中及术后阿片类药物使用的影响。该研究包括三个组：预剂量改变组（n=254）、芬太尼单独改变组（n=102）和后剂量改变组（n=254）。减少阿片类药物单位剂量可减少术中阿片类药物的使用和整个围手术期的使用。所有组比较均观察到麻醉后护理单位吗啡毫克当量（MME）需求减少，但有一组除外。我们的数据表明，阿片类药物单位剂量的使用与管理呈直接比例关系，术中 MME 利用率的降低导致总围手术期 MME 使用的减少。
