Liu Yan, Li Qiang, Zhang Tianyi, Wang Lei, Wang Yarong, Chen Jiajie, Zhu Jia, Shi Hong, Wang Wei, Li Wei
Department of Radiology, Tangdu Hospital, Air Force Medical University, 569 Xinsi Road, BaQiao District, Xi'an, 710038, Shaanxi, China.
Department of Radiology, Xi'an Gem Flower Changqing Hospital, Xi'an, 710018, Shaanxi, China.
Brain Imaging Behav. 2022 Oct;16(5):1973-1982. doi: 10.1007/s11682-022-00667-0. Epub 2022 Aug 26.
Both methamphetamine use disorder (MAUD) and heroin use disorder (HUD) implicated in substance-induced psychosis, but the psychiatirc symptoms induced by MAUD and HUD are significantly different. The functional network organizations that may underlie these differences remains unknown. Image data was acquired by resting-state fMRI from 19 MAUD patients, 21 HUD patients, and 20 healthy controls. The small-world properties, node attributes, and functional connectivity of brain regions were analyzed among the three groups. Psychiatric status was evaluated by the Symptom Checklist 90 in all participants. The MAUD patients had significantly higher psychiatric scores than the controls and HUD patients. Both MAUD and HUD patients still had economical small-world properties. The MAUD patients showed increased nodal efficiency and betweenness centrality in the right inferior occipital gyrus, left insular lobe, bilateral Heschl gyrus, and bilateral superior temporal gyrus, while the node attributes decreased in the right parahippocampal gyrus and right hippocampus compared to the HUD patients. The MAUD patients also showed reduced edge connectivity between left dorsolateral prefrontal cortex (dlPFC) and left middle occipital gyrus (MOG), as well as between bilateral orbitofrontal cortex (OFC) and bilateral superior occipital gyrus (SOG), left MOG, or right cuneus. In the MAUD group, the functional connection between left dlPFC and left MOG was negatively correlated with depression, while the connection between right cuneus lobe and right OFC was negatively correlated with depression and interpersonal sensitivity. These brain regions related to cognitive, emotional, and auditory/visual regulation may play an important role in the psychiatric symptoms of MAUD.
甲基苯丙胺使用障碍（MAUD）和海洛因使用障碍（HUD）均与物质所致精神病有关，但MAUD和HUD所致的精神症状有显著差异。这些差异可能潜在的功能网络组织尚不清楚。通过静息态功能磁共振成像（fMRI）获取了19例MAUD患者、21例HUD患者和20名健康对照者的图像数据。分析了三组之间脑区的小世界属性、节点属性和功能连接性。所有参与者均通过症状自评量表90评估精神状态。MAUD患者的精神评分显著高于对照组和HUD患者。MAUD和HUD患者仍具有经济的小世界属性。MAUD患者右侧枕下回、左侧岛叶、双侧颞横回和双侧颞上回的节点效率和中介中心性增加，而与HUD患者相比，右侧海马旁回和右侧海马的节点属性降低。MAUD患者还表现出左侧背外侧前额叶皮质（dlPFC）与左侧枕中回（MOG）之间以及双侧眶额皮质（OFC）与双侧枕上回（SOG）、左侧MOG或右侧楔叶之间的边缘连接性降低。在MAUD组中，左侧dlPFC与左侧MOG之间的功能连接与抑郁呈负相关，而右侧楔叶与右侧OFC之间的连接与抑郁和人际敏感性呈负相关。这些与认知、情感和听觉/视觉调节相关的脑区可能在MAUD的精神症状中起重要作用。
