[粉末和片剂中药物的多晶型现象。1. 苯巴比妥多晶型变体的制备与表征]
[The polymorphism of drugs in powders and tablets. 1. The preparation and characterization of polymorphic modifications of phenobarbital].
作者信息
Traue J, Kala H, Wenzel U, Wiegeleben A, Pintye-Hódi K, Szabó-Révész P, Miseta M, Selmeczi B, Kedvessy G
出版信息
Pharmazie. 1987 Feb;42(2):86-9.
The characterisation of three phenobarbital modifications by thermic examination procedures (DSC, DTA) is being described. Modification I was obtained by thermic treatment of the brands (modification II) from Hungary and the GDR. The spray product prepared, consisting of very fine hollow spheres, was identified as modification III. Besides the particle size distribution the form of the particle was determined by scanning electron microscopy (REM). The best results regarding saturation solubility and speed of dissolution were found for the spray product.
本文描述了通过热分析程序（差示扫描量热法、差示热分析法）对三种苯巴比妥变体的表征。变体I是通过对来自匈牙利和民主德国的品牌（变体II）进行热处理获得的。所制备的喷雾产品由非常细小的空心球体组成，被鉴定为变体III。除了粒度分布外，还通过扫描电子显微镜（REM）确定了颗粒的形态。喷雾产品在饱和溶解度和溶解速度方面取得了最佳结果。
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