Matzkó-Hollenbach K, Pintye-Hódi K, Kedvessy G
Pharmazie. 1982 Aug;37(8):562-5.
The manufacture of a spray-dried barbital preparation is described, the properties, tabletting behaviour and release of which were studied in comparison to the initial substance. Spray-drying led to a compression-resistant mixture of amorphous and crystalline particles. As most of these particles have a spherical shape, the tablets obtained from this mixture were of great compactness, which inhibited the penetration of the medium and, consequently, delayed the release of the drug, too.
描述了一种喷雾干燥巴比妥制剂的制备方法，并将其性质、压片行为和释放情况与初始物质进行了比较研究。喷雾干燥得到了一种由无定形和结晶颗粒组成的抗压混合物。由于这些颗粒大多呈球形，由该混合物制成的片剂具有很高的致密性，这阻碍了介质的渗透，因此也延迟了药物的释放。
