Truesdell L S, Bodnar R J
Physiol Behav. 1987;39(6):727-31. doi: 10.1016/0031-9384(87)90257-5.
The analgesic response following cold-water swims (CWS) has been shown to be mediated through neurohormonal mechanisms and independently of opioid systems. The hypothalamic paraventricular nucleus (PVN) appears to be important in autonomic, hypophysial and medial-basal hypothalamic function. The present study examined whether lesions placed in the PVN in rats would alter CWS analgesia on the tail-flick test. Animals with lesions placed in the PVN displayed significant reductions in analgesic magnitude 30 (66%) and 60 (54%) min following CWS relative to sham-treated rats without alterations in baseline latencies. In contrast, CWS analgesia was not altered in animals with lesions placed dorsal and/or lateral to the PVN. These data are discussed in terms of the roles of PVN projections to the median eminence and brainstem/spinal structures as well as roles for neuropeptides in the PVN.
冷水游泳（CWS）后的镇痛反应已被证明是通过神经激素机制介导的，且独立于阿片系统。下丘脑室旁核（PVN）在自主神经、垂体及下丘脑内侧基底部功能中似乎起着重要作用。本研究考察了给大鼠PVN部位造成损伤是否会改变其在甩尾试验中的CWS镇痛效果。与假手术处理且基线潜伏期无变化的大鼠相比，PVN部位有损伤的动物在CWS后30分钟（66%）和60分钟（54%）时镇痛强度显著降低。相反，PVN背侧和/或外侧有损伤的动物，其CWS镇痛效果未改变。本文根据PVN向正中隆起和脑干/脊髓结构的投射作用以及PVN中神经肽的作用对这些数据进行了讨论。
