Davis H P, Baranowski J R, Pulsinelli W A, Volpe B T
Physiol Behav. 1987;39(6):783-6. doi: 10.1016/0031-9384(87)90267-8.
Retention of reference memory was evaluated in an animal model of cerebral ischemia. Rats were trained for 70 daily trials on an 8-arm radial maze with 5 arms baited, subjected to 30 minutes of forebrain ischemia, allowed to recover for 30 days, and then tested for an additional 50 trials. Post ischemic (PI) rats demonstrated normal retention of reference memory (p less than 0.05). Working memory was significantly impaired postoperatively (p less than 0.05). Morphologic analysis showed that PI rats had primary loss of pyramidal neurons in the CA1 region of hippocampus.
在脑缺血动物模型中评估参考记忆的保持情况。大鼠在一个有5个臂放置诱饵的8臂放射状迷宫中每天训练70次，经历30分钟的前脑缺血，恢复30天，然后再进行50次测试。缺血后（PI）大鼠表现出正常的参考记忆保持（p<0.05）。术后工作记忆明显受损（p<0.05）。形态学分析表明，PI大鼠海马CA1区的锥体细胞有原发性损失。
