Volpe B T, Davis H P, Towle A, Dunlap W P
Department of Neurology and Neuroscience, Burke Institute for Medical Research, White Plains, New York 10605.
Behav Neurosci. 1992 Jun;106(3):457-64. doi: 10.1037//0735-7044.106.3.457.
Rats were trained for 20 days in a modified T maze to perform an invariant, tactile discrimination and a variable, delayed spatial discrimination, and then were exposed either to 30 min of transient forebrain ischemia or to low- or high-dose ibotenic acid to damage the dorsal hippocampus bilaterally. Only rats exposed to ischemia or high-dose ibotenic acid demonstrated impaired performance during 30 postoperative test days on both aspects of the task (p less than .05). Volume of hippocampal damage did not predict performance. However, the extent of CA1 pyramidal neuron loss correlated significantly with performance on the delayed spatial discrimination (p less than .01). Damage to the dentate gyrus and CA2-3 did not correlate with performance. These results support the view that the hippocampus, in particular the CA1 region, is crucial for certain types of memory performance.
将大鼠在改良的T型迷宫中训练20天，使其执行不变的触觉辨别任务和可变的延迟空间辨别任务，然后将其双侧暴露于30分钟的短暂性前脑缺血或低剂量或高剂量鹅膏蕈氨酸中，以损伤背侧海马体。只有暴露于缺血或高剂量鹅膏蕈氨酸的大鼠在术后30天的测试中，在任务的两个方面都表现出受损（p小于0.05）。海马体损伤的体积并不能预测表现。然而，CA1锥体神经元损失的程度与延迟空间辨别任务的表现显著相关（p小于0.01）。齿状回和CA2-3的损伤与表现无关。这些结果支持了这样一种观点，即海马体，特别是CA1区域，对某些类型的记忆表现至关重要。
