Tabart J, Gallois J R, Marland P, Fleury P
Ann Otolaryngol Chir Cervicofac. 1978 Dec;95(12):733-46.
Typical cases of pollen allergen (hayfever, allergic asthma), together with isolated non-respiratory "equivalent" manifestations (urticaria, eye conditions, headache, etc.), are easy to detect on the basis of skin tests and the clinical history. Such manifestations may also occur in "false pollen allergy", related in most instances by atmospheric moulds (Dematiaceae), sometimes by house dust or dermatophytes (Candida Albicans, Trichophyton sp), by food or by a bacterial infection or allergy. A combination of pollen allergy and false pollen allergy is common. In cases of false pollen allergy the proportion of negative skin reactions would appear to worsen with the repeated use of prolonged action corticosteroid injections, given on a preventive basis. Similarly, these disorders, initially seasonal, change to more chronic manifestations throughout the year. Desensitization with aqueous extracts of allergens ensured the most complete protection against the causes of pollen allergy and false pollen allergy. Allergen extracts percipitated with alun (semi-retard extracts), more effective than tyrosine adsorbates (Pollinex) have the advantage of offering more rapid treatment without the risk of dangerous reactions. The best therapeutic results have obtained over the course of the last ten years, by the authors, combining on each occasion a semi-retard allergen with an aqueous allergen, thereby acquiring the benefit of the adjuvant effect of the first, in a course of ten to fifteen injections per year. Non specific therapy (antihistamines, cromoglycate, theophylline, etc.) retains all of its symptomatic indications. Oral corticosteroid therapy is better metabolized in the organism and has less of a disturbing effect on the circadian rhythm of cortisol, and is hence to be preferred to injections of delyaed action corticosteroid suspensions.
典型的花粉过敏原病例(花粉症、过敏性哮喘),以及孤立的非呼吸道“等效”表现(荨麻疹、眼部疾病、头痛等),基于皮肤试验和临床病史很容易检测出来。此类表现也可能出现在“假花粉过敏”中,在大多数情况下与大气霉菌(皮肤癣菌科)有关,有时与屋尘或皮肤真菌(白色念珠菌、毛癣菌属)、食物或细菌感染或过敏有关。花粉过敏和假花粉过敏同时存在的情况很常见。在假花粉过敏病例中,预防性反复使用长效皮质类固醇注射后,皮肤反应阴性的比例似乎会恶化。同样,这些疾病最初是季节性的,会转变为全年更慢性的表现。用过敏原的水性提取物进行脱敏可确保对花粉过敏和假花粉过敏的病因提供最全面的保护。用明矾沉淀的过敏原提取物(半缓释提取物)比酪氨酸吸附剂(Pollinex)更有效,具有提供更快治疗且无危险反应风险的优点。在过去十年中,作者通过每次将半缓释过敏原与水性过敏原联合使用,在每年进行十至十五次注射的疗程中,获得了最佳治疗效果,从而获得了前者的佐剂效应。非特异性疗法(抗组胺药、色甘酸、茶碱等)仍保留其所有对症适应症。口服皮质类固醇疗法在体内代谢更好,对皮质醇的昼夜节律干扰较小,因此比注射长效皮质类固醇混悬液更可取。