Stabler B, Surwit R S, Lane J D, Morris M A, Litton J, Feinglos M N
Psychosom Med. 1987 May-Jun;49(3):313-6. doi: 10.1097/00006842-198705000-00010.
We studied the relationship between presence of Type A behavior pattern and glycemic response to stress in children with insulin dependent diabetes mellitus (IDDM). Twelve male (six Type A and six Type B) and nine female (four Type A and five Type B) insulin-dependent diabetic patients between the ages of 8 and 16 years received a standard meal and blood glucose values were assessed two hours later. All subjects then played a competitive videogame for 10 minutes following which blood glucose was assessed again. Preprandial and postprandial blood glucose values did not differ between the groups. However, only Type A subjects showed a hyperglycemic response to the videogame stress. Type A subjects also demonstrated significantly higher glycohemoglobin values. In order to assure that this effect was due to a differential response to stress and not simply a difference in metabolic response to a meal, a second study was conducted in which blood glucose values were assessed at one, two and three hours following a standard meal. No significant differences in postprandial blood glucose values were observed between Type A and Type B subjects. These data support previous research which has suggested that some but not all patients with IDDM show a hyperglycemic response to stress.
我们研究了胰岛素依赖型糖尿病（IDDM）患儿的A型行为模式与应激血糖反应之间的关系。12名年龄在8至16岁之间的男性（6名A型和6名B型）和9名女性（4名A型和5名B型）胰岛素依赖型糖尿病患者接受了标准餐，两小时后评估血糖值。然后所有受试者玩了10分钟的竞争性电子游戏，之后再次评估血糖。两组之间餐前和餐后血糖值没有差异。然而，只有A型受试者对电子游戏应激表现出高血糖反应。A型受试者的糖化血红蛋白值也显著更高。为了确保这种效应是由于对应激的不同反应，而不仅仅是对一餐的代谢反应差异，进行了第二项研究，在标准餐后1小时、2小时和3小时评估血糖值。A型和B型受试者之间餐后血糖值没有观察到显著差异。这些数据支持了先前的研究，该研究表明，部分但并非所有IDDM患者对应激表现出高血糖反应。
