Gross N J, Narine K R, Colletti-Squinto L
Radiat Res. 1987 Jul;111(1):143-50.
We investigated the replicative activity of type 2 cells in the lungs of mice at various times from 3 to 22 weeks after 18 Gy of X rays to the thorax. No significant changes were found until 11 weeks after thoracic X irradiation. Thereafter the replicative index of type 2 cells was significantly elevated, rising four to sixfold above that of control, sham-irradiated mice. During the period when the replicative activity of type 2 cells was elevated, the breathing frequency increased and there was histologic evidence of the presence of radiation pneumonitis. The magnitude of each of these indices of pneumonitis correlated significantly with the type 2 cell replicative index, suggesting that type 2 cell replication is related to pneumonitis in extent as well as in chronology. How these changes relate to the pathogenesis of radiation pneumonitis is unclear.
我们研究了对小鼠胸部进行18 Gy X射线照射后3至22周内不同时间点小鼠肺内2型细胞的增殖活性。在胸部X线照射后11周之前未发现显著变化。此后，2型细胞的增殖指数显著升高，比假照射的对照小鼠高出四至六倍。在2型细胞增殖活性升高的期间，呼吸频率增加，并且有放射性肺炎存在的组织学证据。这些肺炎指标中的每一项的严重程度与2型细胞增殖指数显著相关，表明2型细胞复制在程度和时间顺序上均与放射性肺炎有关。这些变化与放射性肺炎的发病机制如何相关尚不清楚。
