Woggon B
Pharmakopsychiatr Neuropsychopharmakol. 1977 May;10(3):140-6. doi: 10.1055/s-0028-1094531.
From the clinical examinators point of view, we present a few problems in planning psychopharmacological trials. Our main topic is not answering the questions but formulating them in a more precise manner. The following problems are discussed: formulation of hypotheses, choice of experimental designs (open, double-blind, placebo-controlled), effects of placebo, choice of reference substances, duration of trials, pharmacopsychiatric acute trials, frequence and interval of assessments, size and kind of patient sample, fixed or flexible dosage schedule, pretreatment, wash-out, additional medication, choice of the assessement instrument and double assessment of the initial values.
从临床检查者的角度来看，我们提出了一些在规划精神药理学试验时存在的问题。我们的主要议题不是回答问题，而是更精确地提出问题。讨论了以下问题：假设的制定、实验设计的选择（开放、双盲、安慰剂对照）、安慰剂的作用、参比物质的选择、试验持续时间、药物精神病学急性试验、评估的频率和间隔、患者样本的规模和类型、固定或灵活的给药方案、预处理、洗脱期、辅助用药、评估工具的选择以及初始值的双重评估。
