Bobon D P
Acta Psychiatr Belg. 1978 Jul-Aug;78(4):635-45.
Before the development of audiovisual techniques, it was impossible to avoid two time-related biases in drug evaluation: rating on different occasions, i.e. in different mood states as regards the rater (the so-called time-gap); knowledge by the rater of the sequence of his ratings. In order to make a time-blind evaluation possible, the author has worked out the following steps: tape-recording of the interviews, standardization of the interview, elimination of questions endangering a time-blind analysis, evaluation of the different interviews of the same patient on different rating sessions. The author summarizes his first three drug trials analyzed according to the time-blind procedure, and concludes that this procedure is a definite progress regarding the validity of drug research.
在视听技术发展之前，药物评估中不可避免地存在两种与时间相关的偏差：在不同场合进行评分，即评分者处于不同情绪状态（所谓的时间间隔）；评分者知晓其评分顺序。为了实现时间盲法评估，作者制定了以下步骤：对访谈进行录音、使访谈标准化、消除危及时间盲法分析的问题、对同一患者在不同评分时段的不同访谈进行评估。作者总结了根据时间盲法程序分析的前三项药物试验，并得出结论，就药物研究的有效性而言，该程序是一个明确的进步。
