Kaplan P A, Asleson R J, Klassen L W, Duggan M J
Radiology. 1987 Aug;164(2):441-4. doi: 10.1148/radiology.164.2.3602384.
Six patients diagnosed as having aplastic anemia underwent magnetic resonance (MR) imaging. The bone marrow in the lumbar spine, pelvis, and proximal femora was examined in each case. One patient had a normal marrow signal intensity (SI) and pattern and was considered cured of disease. The other patients had varying numbers of focal low-SI areas interspersed with high-SI areas in the marrow of the spine. The pelves and proximal femora of all patients had diffuse high-SI marrow without focal abnormalities. Biopsy of a lumbar vertebral body in one patient demonstrated that the focal low-SI areas may have been islands of active hematopoietic cells scattered in otherwise fatty marrow. MR may prove to be a valuable, noninvasive method of following the response of patients with aplastic anemia to therapy; more investigation is necessary before this can be definitely concluded.
六名被诊断为再生障碍性贫血的患者接受了磁共振（MR）成像检查。对每位患者的腰椎、骨盆和股骨近端骨髓进行了检查。一名患者的骨髓信号强度（SI）和模式正常，被认为疾病已治愈。其他患者的脊柱骨髓中有数量不等的局灶性低SI区域，其间夹杂着高SI区域。所有患者的骨盆和股骨近端骨髓均呈弥漫性高SI，无局灶性异常。对一名患者的腰椎椎体进行活检显示，局灶性低SI区域可能是散布在其他脂肪骨髓中的活跃造血细胞岛。MR可能被证明是一种有价值的、非侵入性的方法，用于跟踪再生障碍性贫血患者对治疗的反应；在得出明确结论之前，还需要更多的研究。
