Disse B G, Ziegler H W
Respiration. 1987;51 Suppl 1:15-22. doi: 10.1159/000195270.
The mucokinetic activity of ambroxol was demonstrated as an increase in mucus or particle transport rate on the frog palate and in guinea pig tracheas. To clarify the mechanism we examined the influence of the drug on the ciliary beat frequency (CBF) of isolated cells from guinea pig tracheas. Ambroxol significantly stimulated the CBF up to 10.8%, salbutamol up to 19.5%. The effect of ambroxol on CBF certainly contributes to, but does not explain the more pronounced increase in transport rate. Thus a stimulation of the mucociliary transport rate by the other major pharmacodynamic mechanisms, secretagogue activity and stimulation of pulmonary surfactant, has to be considered. The therapeutic activity of ambroxol in models of the infant and adult respiratory distress syndrome and of the chronic bronchitic syndrome is reviewed.
氨溴索的促黏液运动活性表现为在蛙腭和豚鼠气管中黏液或颗粒转运速率的增加。为阐明其机制，我们研究了该药物对豚鼠气管分离细胞的纤毛摆动频率（CBF）的影响。氨溴索显著刺激CBF增加高达10.8%，沙丁胺醇增加高达19.5%。氨溴索对CBF的作用肯定有助于，但不能解释转运速率更明显的增加。因此，必须考虑通过其他主要药效学机制（促分泌活性和肺表面活性物质的刺激）来刺激黏液纤毛转运速率。本文综述了氨溴索在婴儿和成人呼吸窘迫综合征以及慢性支气管炎综合征模型中的治疗活性。
