Uchida M, Noguchi Y, Arakawa R, Hashimoto Y, Ikarashi Y, Honda H
Pharmacological Research Laboratories, Grelan Pharmaceutical Co., Ltd., Tokyo, Japan.
Nihon Yakurigaku Zasshi. 1992 Oct;100(4):293-300. doi: 10.1254/fpj.100.293.
The effects of orally administered ambroxol HCl (ambroxol) on guinea pig tracheal mucous secretion and rat pulmonary surfactant secretion were investigated histologically and biochemically. Ambroxol significantly increased the number of active goblet cells in guinea pig tracheal epithelium and total mucopolysaccharide level. Moreover, ambroxol significantly increased the neutral mucopolysaccharide level and PAS-positive substance in the guinea pig tracheal submucosal glands. Ambroxol did not show a significant effect on the content of the total phosphatidylcholine in rat lung lavage fluid, while ambroxol significantly increased the ratio of disaturated phosphatidylcholine to total phosphatidylcholine. From these results, it is suggested that ambroxol increases both the tracheal mucous secretion, especially the neutral mucopolysaccharide, and pulmonary surfactant secretion and these effects reflect part of the expectorant mechanism of the drug.
通过组织学和生物化学方法研究了口服盐酸氨溴索（氨溴索）对豚鼠气管黏液分泌及大鼠肺表面活性物质分泌的影响。氨溴索显著增加了豚鼠气管上皮中活性杯状细胞的数量及总黏多糖水平。此外，氨溴索显著增加了豚鼠气管黏膜下腺中的中性黏多糖水平及过碘酸雪夫（PAS）阳性物质。氨溴索对大鼠肺灌洗液中总磷脂酰胆碱的含量未显示出显著影响，而氨溴索显著增加了二饱和磷脂酰胆碱与总磷脂酰胆碱的比例。从这些结果表明，氨溴索可增加气管黏液分泌，尤其是中性黏多糖，以及肺表面活性物质分泌，这些作用反映了该药物祛痰机制的一部分。
