Jeyaranjan R, Goode R, Beamish S, Duffin J
Respir Physiol. 1987 May;68(2):203-13. doi: 10.1016/s0034-5687(87)80006-3.
The purpose of this study was to determine, in man, the contribution of peripheral chemoreceptors to ventilation during constant-load, heavy exercise above anaerobic threshold at sea level, using hyperoxic suppression of peripheral chemoreceptor drive which was obtained by abrupt and surreptitious replacement of inspired air with 100% oxygen for a period of 20-30 sec during the exercise. There was a delay of at least 1 sec from the time of peripheral chemoreceptor blockade to the initial change in ventilation, suggesting the operation of a central neural reverberatory mechanism after the cessation of peripheral chemoreceptor drive. In contrast to Wasserman (1976), whose results indicated a 25% decrease in ventilation within two breaths, in the present study no significant drop was observed until some 4-6 breaths after the air-to-oxygen switch. Furthermore, the drop in ventilation, magnitude of which was of the order of 15%, was transient in 5 out of 8 subjects. In one subject, the ventilation increased following oxygen administration. It is concluded that the peripheral chemoreceptors are not the sole mediators of hyperventilation of heavy exercise above anaerobic threshold in man.
本研究的目的是在海平面上，通过在运动过程中用100%氧气突然秘密替换吸入空气20 - 30秒以实现外周化学感受器驱动的高氧抑制，来确定在恒定负荷下、高于无氧阈值的重度运动期间外周化学感受器对人体通气的贡献。从外周化学感受器被阻断到通气开始变化至少有1秒的延迟，这表明在外周化学感受器驱动停止后存在中枢神经反射机制在起作用。与Wasserman（1976）的结果不同，他的结果表明在两次呼吸内通气量下降25%，而在本研究中，直到空气换为氧气后约4 - 6次呼吸才观察到明显下降。此外，8名受试者中有5名的通气量下降幅度约为15%，且是短暂的。在一名受试者中，给予氧气后通气量增加。结论是，外周化学感受器不是人体高于无氧阈值的重度运动时过度通气的唯一介导因素。
