College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710062, Shaanxi, China.
J Agric Food Chem. 2022 Sep 14;70(36):11377-11390. doi: 10.1021/acs.jafc.2c03289. Epub 2022 Aug 26.
The present study compared the modulatory effects of different resistant starches (RSs) isolated from native (NP-RS), acid-hydrolyzed (AHP-RS), and pullulanase debranched (PDP-RS) pea starches on the corresponding metabolic responses in high fat (HF)-diet-induced obese mice. The biochemical studies on serum lipid profile and antioxidant enzyme activities were supported by histological and gene expression analyses, which suggested a potential therapeutic role for RS in regulating obesity, possibly through the production of short-chain fatty acids and the proliferation of some beneficial colonic bacteria, including , , , , and . Particularly, a more pronounced effect of AHP-RS with a higher proportion of the crystalline region and a more ordered double-helical alignment on improving the hyperlipidemic symptoms in obese mice induced by a HF diet was observed. Our analysis revealed that the RS3 samples seemed to be more effective than RS2 in terms of attenuating obesity in mice that were fed a HF diet.
本研究比较了从天然（NP-RS）、酸水解（AHP-RS）和普鲁兰酶支链淀粉（PDP-RS）豌豆淀粉中分离得到的不同抗性淀粉（RS）对高脂肪（HF）饮食诱导肥胖小鼠相应代谢反应的调节作用。血清脂质谱和抗氧化酶活性的生化研究得到了组织学和基因表达分析的支持，这表明 RS 在调节肥胖方面可能具有潜在的治疗作用，可能是通过产生短链脂肪酸和某些有益的结肠细菌的增殖，包括 、 、 、 、 。特别是，观察到具有更高比例结晶区和更有序的双螺旋排列的 AHP-RS 对改善 HF 饮食诱导肥胖小鼠的高脂血症症状具有更显著的效果。我们的分析表明，在减轻 HF 饮食喂养的肥胖小鼠的肥胖方面，RS3 样品似乎比 RS2 更有效。
