Faculty of Health and Social Sciences, Bournemouth University, Bournemouth, United Kingdom.
Academic Department of Military Rehabilitation, Defence Medical Rehabilitation Centre, Stanford Hall, Loughborough, United Kingdom.
PLoS One. 2022 Aug 26;17(8):e0273688. doi: 10.1371/journal.pone.0273688. eCollection 2022.
Heart Rate Variability (HRV) is an indirect measure of autonomic function. Attenuated HRV is linked to worsening health outcomes including Major Adverse Cardiovascular Events (MACE). The relationship between traumatic injury (TI) and HRV has been limitedly studied. This research protocol has been designed to conduct a systematic review of the existing evidence on the association between non-acute TI and HRV in adults. Four electronic bibliographic databases (Web of Science, CINAHL, Medline, and Scopus) will be searched. The studies on non-acute (>7 days post injury) TI and HRV in adults will be included, followed by title-abstract screening by two reviewers independently. The quality and risk of bias of the included studies will be assessed using Axis and a six-item Risk of Bias Assessment tool for of Non-randomized Studies (RoBANS) respectively. Grading of Recommendations Assessment, Development and Evaluation (GRADE) will assess the quality of evidence. The extracted data will be synthesized using narrative syntheses and a Forest plot with or without meta-analysis- whichever permitted by the pooled data. This will be the first systematic review to examine the relationship between generalized TI and HRV in adults. Trial registration: (PROPSERO registration number: CRD: CRD42021298530) https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021298530.
心率变异性（HRV）是自主功能的间接测量指标。HRV 减弱与健康状况恶化有关，包括主要不良心血管事件（MACE）。创伤性损伤（TI）与 HRV 之间的关系研究有限。本研究方案旨在对成人非急性 TI 与 HRV 之间关联的现有证据进行系统评价。将检索四个电子文献数据库（Web of Science、CINAHL、Medline 和 Scopus）。纳入成人非急性（>7 天伤后）TI 和 HRV 的研究，并由两名评审员独立进行标题-摘要筛选。使用 Axis 和六条目非随机研究偏倚风险评估工具（RoBANS）分别评估纳入研究的质量和偏倚风险。推荐评估、制定和评估（GRADE）将评估证据质量。使用叙述性综合和森林图（如果允许进行荟萃分析）综合提取的数据。这将是第一项系统评价，旨在检查成人普遍 TI 与 HRV 之间的关系。试验注册：（PROPSERO 注册号：CRD: CRD42021298530）https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021298530。
