Program in Occupational Therapy, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Department of Neurology, Washington University School of Medicine, St. Louis, MO, 63108, USA.
Neurosci Biobehav Rev. 2021 Dec;131:737-754. doi: 10.1016/j.neubiorev.2021.10.004. Epub 2021 Oct 6.
This review aimed to quantify correlations between heart rate variability (HRV) and functional outcomes after acquired brain injury (ABI). We conducted a literature search from inception to January 2020 via electronic databases, using search terms with HRV, ABI, and functional outcomes. Meta-analyses included 16 studies with 906 persons with ABI. Results demonstrated significant associations: Low frequency (LF) (r = -0.28) and SDNN (r = -0.33) with neurological function; LF (r = -0.33), High frequency (HF) (r = -0.22), SDNN (r = -0.22), and RMSSD (r = -0.23) with emotional function; and LF (r = 0.34), HF (r = 0.41 to 0.43), SDNN (r = 0.43 to 0.51), and RMSSD (r = 0.46) with behavioral function. Results indicate that higher HRV is related to better neurological, emotional, and behavioral functions after ABI. In addition, persons with stroke showed lower HF (SMD = -0.50) and SDNN (SMD = -0.75) than healthy controls. The findings support the use of HRV as a biomarker to facilitate precise monitoring of post-ABI functions.
本综述旨在量化心率变异性（HRV）与获得性脑损伤（ABI）后功能结果之间的相关性。我们通过电子数据库从创建到 2020 年 1 月进行了文献检索，使用了包含 HRV、ABI 和功能结果的搜索词。荟萃分析纳入了 16 项研究共 906 名 ABI 患者。结果表明存在显著相关性：低频（LF）（r = -0.28）和 SDNN（r = -0.33）与神经功能相关；LF（r = -0.33）、高频（HF）（r = -0.22）、SDNN（r = -0.22）和 RMSSD（r = -0.23）与情绪功能相关；LF（r = 0.34）、HF（r = 0.41 至 0.43）、SDNN（r = 0.43 至 0.51）和 RMSSD（r = 0.46）与行为功能相关。结果表明，HRV 较高与 ABI 后神经、情绪和行为功能的改善相关。此外，与健康对照组相比，脑卒中患者的 HF（SMD = -0.50）和 SDNN（SMD = -0.75）较低。这些发现支持将 HRV 用作生物标志物，以促进对 ABI 后功能的精确监测。
