Ponge T, Mussini J M, Ponge A, Forgeau Y, Barrier J, Cottin S, Grolleau J Y
Rev Neurol (Paris). 1987;143(2):147-8.
A 61-year-old woman was admitted for acute arthralgias and proximal weakness in all four limbs. Clinical examination found xerostomia, xerophthalmia, enlarged parotid glands. The Schirmer test was positive and the salivary gland biopsy showed a mononuclear, lymphoid, sometimes nodular infiltrate. A muscle biopsy showed necrotizing myopathy with perifascicular atrophy. The patient refused steroids and was given hydroxychloroquine (600 mg daily). She improved gradually, and one year later there were no further complications. The favorable course both of Sjögren's syndrome and polymyositis with hydroxychloroquine treatment is unexpected. This led us to suppose that both could have had a common cause.
一名61岁女性因急性关节痛和四肢近端无力入院。临床检查发现口干、眼干、腮腺肿大。施密特试验呈阳性，唾液腺活检显示单核、淋巴样，有时呈结节状浸润。肌肉活检显示坏死性肌病伴束周萎缩。患者拒绝使用类固醇，给予羟氯喹（每日600毫克）。她逐渐好转，一年后未出现进一步并发症。干燥综合征和多发性肌炎经羟氯喹治疗后病程良好，这出乎意料。这使我们推测两者可能有共同病因。
