Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, New York, USA; email:
Annu Rev Pharmacol Toxicol. 2023 Jan 20;63:143-163. doi: 10.1146/annurev-pharmtox-051921-020812. Epub 2022 Aug 26.
Air pollution is a complex mixture of gases and particulate matter, with adsorbed organic and inorganic contaminants, to which exposure is lifelong. Epidemiological studies increasingly associate air pollution with multiple neurodevelopmental disorders and neurodegenerative diseases, findings supported by experimental animal models. This breadth of neurotoxicity across these central nervous system diseases and disorders likely reflects shared vulnerability of their inflammatory and oxidative stress-based mechanisms and a corresponding ability to produce brain metal dyshomeo-stasis. Future research to define the responsible contaminants of air pollution underlying this neurotoxicity is critical to understanding mechanisms of these diseases and disorders and protecting public health.
空气污染是一种复杂的气体和颗粒物混合物，吸附有机和无机污染物，暴露是终身的。越来越多的流行病学研究将空气污染与多种神经发育障碍和神经退行性疾病联系起来，这些发现得到了实验动物模型的支持。这种横跨这些中枢神经系统疾病和障碍的神经毒性的广泛性可能反映了它们基于炎症和氧化应激的机制的共同脆弱性，以及相应的产生脑金属动态失衡的能力。未来研究空气污染中导致神经毒性的责任污染物对于理解这些疾病和障碍的机制和保护公众健康至关重要。
