Centre for Inflammation Research and Institute of Regeneration and Repair, University of Edinburgh, Edinburgh, UK
Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
Eur Respir J. 2022 Dec 1;60(6). doi: 10.1183/13993003.01521-2022. Print 2022 Dec.
SARS-CoV-2 has caused devastating effects with over 550 million infections by July 2022 and approximately 6.4 million deaths [1]. Societal and economic impacts will reverberate for years, with continuous evolution of SARS-CoV-2 as it persistently spreads through the human population as exemplified by reduced activity of vaccines and monoclonals against Omicron BA.4 or BA.5 subvariants [2]. A greater understanding of pathogenesis and more tailored therapeutic approaches are therefore essential.
截至 2022 年 7 月，SARS-CoV-2 已导致超过 5.5 亿例感染，造成约 640 万人死亡[1]。随着 SARS-CoV-2 在人群中持续传播，其不断进化，例如疫苗和单克隆抗体对奥密克戎 BA.4 或 BA.5 亚变体的活性降低[2]，社会和经济影响将持续多年。因此，我们需要更深入地了解发病机制，并采用更有针对性的治疗方法。
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