生长激素释放肽和瘦素对创伤愈合的调节作用。
Ghrelin and leptin regulating wound healing.
机构信息
Equipe labellisée par la Ligue contre le Cancer, Université de Paris Cité, Sorbonne Université, Institut Universitaire de France, Inserm U1138, Centre de Recherche des Cordeliers, Paris, France; Metabolomics and Cell Biology Platforms, Gustave Roussy Comprehensive Cancer Institute, Villejuif, France; Institut du Cancer Paris CARPEM, Department of Biology, Hôpital Européen Georges Pompidou, AP-HP, Paris, France.
INSERM U1015, Equipe Labellisée - Ligue Nationale contre le Cancer, Villejuif, France; Department of Medical Oncology, Gustave Roussy Cancer Campus, Villejuif, France; Gustave Roussy, ClinicObiome, Villejuif, France; Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 1428, Villejuif, France.
出版信息
Trends Immunol. 2022 Oct;43(10):777-779. doi: 10.1016/j.it.2022.08.005. Epub 2022 Aug 23.
A recent article by Kratofil et al. investigated the immune inflammatory response against Staphylococcus aureus-contaminated foreign bodies placed under mouse skin. In this model, neutrophils are indispensable for bacterial clearance, while monocyte-derived macrophages are required for optimal wound healing. Intriguingly, ghrelin produced by macrophages favors, and leptin produced by hypodermal adipocytes inhibits, an adequate foreign body response.
最近，Kratofil 等人研究了在小鼠皮肤下放置的受金黄色葡萄球菌污染的异物的免疫炎症反应。在该模型中，中性粒细胞对细菌清除不可或缺，而单核细胞衍生的巨噬细胞则对最佳伤口愈合至关重要。有趣的是，巨噬细胞产生的生长素释放肽有利于异物反应，而真皮脂肪细胞产生的瘦素则抑制异物反应。
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