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液体浸润的微结构化生物黏合剂可止住不可压缩性出血。

Liquid-infused microstructured bioadhesives halt non-compressible hemorrhage.

机构信息

Department of Mechanical Engineering, McGill University, Montreal, QC, Canada.

Faculty of Dentistry, McGill University, Montreal, QC, Canada.

出版信息

Nat Commun. 2022 Aug 26;13(1):5035. doi: 10.1038/s41467-022-32803-1.

Abstract

Non-compressible hemorrhage is an unmet clinical challenge that accounts for high mortality in trauma. Rapid pressurized blood flows under hemorrhage impair the function and integrity of hemostatic agents and the adhesion of bioadhesive sealants. Here, we report the design and performance of bioinspired microstructured bioadhesives, formed with a macroporous tough xerogel infused with functional liquids. The xerogel can rapidly absorb interfacial fluids such as whole blood and promote blood clotting, while the infused liquids facilitate interfacial bonding, sealing, and antibacterial function. Their synergy enables the bioadhesives to form tough adhesion on ex vivo human and porcine tissues and diverse engineered surfaces without the need for compression, as well as on-demand instant removal and storage stability. We demonstrate a significantly improved hemostatic efficacy and biocompatibility in rats and pigs compared to non-structured counterparts and commercial products. This work opens new avenues for the development of bioadhesives and hemostatic sealants.

摘要

不可压缩性出血是创伤导致高死亡率的未满足临床挑战。在出血情况下,快速加压血流会损害止血剂的功能和完整性以及生物黏合剂密封剂的黏附性。在这里,我们报告了仿生微结构生物黏合剂的设计和性能,该生物黏合剂由大孔坚韧的气凝胶和功能液体组成。气凝胶可以快速吸收全血等界面液体并促进血液凝固,而注入的液体则有助于界面黏合、密封和抗菌功能。它们的协同作用使生物黏合剂能够在无需加压的情况下在离体的人和猪组织以及各种工程表面上形成坚韧的黏附,还能够按需即时去除并具有储存稳定性。与非结构化的对应物和商业产品相比,我们在大鼠和猪身上证明了显著提高的止血效果和生物相容性。这项工作为生物黏合剂和止血密封剂的发展开辟了新途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a4d/9418157/9d8590911277/41467_2022_32803_Fig1_HTML.jpg

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