Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai, 200011, People's Republic of China.
School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, People's Republic of China.
J Nanobiotechnology. 2022 Aug 26;20(1):388. doi: 10.1186/s12951-022-01594-4.
The anticancer treatment is largely affected by the microenvironment of the tumors, which not only resists the tumors to the thermo/chemo-therapy, but also promotes their growth and invasion. In this work, the angiogenesis factor is balanced by combining with the breathing hyperoxygen, for regulating the tumor microenvironment and also for relieving hypoxia and high tissue interstitial pressure, which promote drug delivery to tumor tissues by increasing the in vivo perfusion and reversing the immunosuppressive tumor. In addition, the designed multifunctional nanoparticles have a great potential for applications to the tumor dual-mode imaging including magnetic resonance (MR) and photoacoustic (PA) imaging. This work proposes a promising strategy to enhance the thermo/chemo-therapy efficacy by remodeling the tumor microenvironment, which would provide an alternative to prolong the lifetime of tumor patients.
癌症治疗在很大程度上受到肿瘤微环境的影响，肿瘤微环境不仅能抵抗热疗/化疗，还能促进肿瘤的生长和侵袭。在这项工作中，通过与呼吸性高氧结合来平衡血管生成因子，从而调节肿瘤微环境，并缓解缺氧和高组织间质压力，通过增加体内灌注和逆转免疫抑制肿瘤来促进药物输送到肿瘤组织。此外，设计的多功能纳米粒子具有很大的潜力应用于肿瘤的双模式成像，包括磁共振成像（MR）和光声（PA）成像。这项工作提出了一种有前途的策略，通过重塑肿瘤微环境来增强热疗/化疗的疗效，这为延长肿瘤患者的寿命提供了一种替代方法。
