Meng Wenjun, Huang Li, Guo Jiamin, Xin Qing, Liu Jiyan, Hu Yuzhu
Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China.
Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China.
Pharmaceutics. 2024 Dec 3;16(12):1549. doi: 10.3390/pharmaceutics16121549.
Nanodrug delivery systems have revolutionized tumor therapy like never before. By overcoming the complexity of the tumor microenvironment (TME) and bypassing drug resistance mechanisms, nanotechnology has shown great potential to improve drug efficacy and reduce toxic side effects. This review examines the impact of the TME on drug resistance and recent advances in nanomedicine delivery systems to overcome this challenge. Characteristics of the TME such as hypoxia, acidity, and high interstitial pressure significantly reduce the effectiveness of chemotherapy and radiotherapy, leading to increased drug resistance in tumor cells. Then, this review summarizes innovative nanocarrier designs for these microenvironmental features, including hypoxia-sensitive nanoparticles, pH-responsive carriers, and multifunctional nanosystems that enable targeted drug release and improved drug penetration and accumulation in tumors. By combining nanotechnology with therapeutic strategies, this review offers a novel perspective by focusing on the innovative design of nanocarriers that interact with the TME, a dimension often overlooked in similar reviews. We highlight the dual role of these nanocarriers in therapeutic delivery and TME modulation, emphasize their potential to overcome drug resistance, and look at future research directions.
纳米药物递送系统彻底改变了肿瘤治疗，前所未有的变革。通过克服肿瘤微环境（TME）的复杂性并绕过耐药机制，纳米技术已显示出提高药物疗效和减少毒副作用的巨大潜力。本综述探讨了TME对耐药性的影响以及纳米医学递送系统为克服这一挑战所取得的最新进展。TME的特征，如缺氧、酸性和高间质压力，显著降低了化疗和放疗的效果，导致肿瘤细胞耐药性增加。然后，本综述总结了针对这些微环境特征的创新纳米载体设计，包括缺氧敏感纳米颗粒、pH响应载体以及能够实现靶向药物释放并改善药物在肿瘤中的渗透和积累的多功能纳米系统。通过将纳米技术与治疗策略相结合，本综述通过关注与TME相互作用的纳米载体的创新设计提供了一个新颖的视角，这是类似综述中经常被忽视的一个维度。我们强调了这些纳米载体在治疗递送和TME调节中的双重作用，强调了它们克服耐药性的潜力，并展望了未来的研究方向。
