2型糖尿病患者中晚期糖基化终末产物（AGEs）与ABC（糖化血红蛋白、血压和低密度脂蛋白胆固醇）控制参数之间的关联。
The association between advanced glycation end products (AGEs) and ABC (hemoglobin A1C, blood pressure, and low-density lipoprotein cholesterol) control parameters among patients with type 2 diabetes mellitus.
作者信息
Rezaei Mohaddeseh, Rabizadeh Soghra, Mirahmad Maryam, Hajmiri Minoo Sadat, Nakhjavani Manouchehr, Hemmatabadi Mahboobeh, Shirzad Nooshin
机构信息
Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Department of Endocrinology, Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Diabetol Metab Syndr. 2022 Aug 26;14(1):122. doi: 10.1186/s13098-022-00895-w.
BACKGROUND
Diabetes-induced chronic hyperglycemia results in the formation and aggregation of advanced glycation end-products (AGEs), which are products of non-enzymatic glycosylation of lipids or proteins. The development of diabetic complications can be accelerated by AGEs. In the current study, we aimed to explore the relationship between AGEs levels and ABC goals of diabetes control (A: Hemoglobin A1C < 7.0%, B: Blood pressure < 140/90 mmHg, and C: low-density lipoprotein cholesterol [LDL] < 100 mg/dL).
METHODS
In the current cross-sectional study, 293 patients with type 2 diabetes mellitus (T2D), were enrolled. Demographic and clinical characteristics of the individuals were collected. AGEs levels were measured using quantitative fluorescence spectroscopy. Finally, the association of AGEs levels with patients' characteristics and ABC goals was assessed.
RESULTS
Higher serum AGEs concentration was detected in older age, smoking patients and those with higher diastolic blood pressure, lower high-density lipoprotein (HDL) level, lower body mass index (BMI) and retinopathy. Moreover, the T2D patients who achieved higher numbers of ABC goals of diabetes were younger age (P-value = 0.003), with lower hemoglobin A1C (P-value = 0.001), fasting blood sugar (P-value = 0.002) diastolic blood pressure (P-value = 0.001), systolic blood pressure (P-value = 0.001), cholesterol (P-value = 0.001), LDL (P-value = 0.001), and AGEs (P-value = 0.023) levels. Diabetic patients with AGEs levels above 73.9% were about 2.2 times more likely to achieve none of ABC treatment goals (95% CI 1.107-3.616).
CONCLUSION
Our results revealed the relationship between AGEs and ABC goal achievement, and microvascular diabetic complications, and imply that AGEs measurement may be valuable in the monitoring of diabetic patients' complications and treatment adjustment.
背景
糖尿病引起的慢性高血糖会导致晚期糖基化终产物（AGEs）的形成和聚集，AGEs是脂质或蛋白质非酶糖基化的产物。AGEs会加速糖尿病并发症的发展。在本研究中，我们旨在探讨AGEs水平与糖尿病控制的ABC目标之间的关系（A：糖化血红蛋白A1C＜7.0%，B：血压＜140/90 mmHg，C：低密度脂蛋白胆固醇[LDL]＜100 mg/dL）。
方法
在本次横断面研究中，纳入了293例2型糖尿病（T2D）患者。收集了个体的人口统计学和临床特征。使用定量荧光光谱法测量AGEs水平。最后，评估了AGEs水平与患者特征及ABC目标之间的关联。
结果
在老年、吸烟患者以及舒张压较高、高密度脂蛋白（HDL）水平较低、体重指数（BMI）较低和患有视网膜病变的患者中，检测到较高的血清AGEs浓度。此外，实现更多糖尿病ABC目标的T2D患者年龄较小（P值=0.003），糖化血红蛋白A1C较低（P值=0.001）、空腹血糖较低（P值=0.002）、舒张压较低（P值=0.001）、收缩压较低（P值=0.001）、胆固醇较低（P值=0.001）、LDL较低（P值=0.001）以及AGEs水平较低（P值=0.023）。AGEs水平高于73.9%的糖尿病患者未达到ABC治疗目标的可能性约为2.2倍（95%置信区间1.107 - 3.616）。
结论
我们的结果揭示了AGEs与ABC目标实现以及糖尿病微血管并发症之间的关系，并表明测量AGEs可能对监测糖尿病患者的并发症和调整治疗具有重要价值。
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