Ludhiadch Abhilash, Yadav Pooja, Singh Sunil Kumar, Munshi Anjana
Complex Disease Genomics and Precision Medicine Laboratory, Department of Human Genetics and Molecular Medicine, Central University of Punjab, Ghudda, Bathinda, Punjab, India.
Department of Zoology, Central University of Punjab, Ghudda, Bathinda, Punjab, India.
Int J Neurosci. 2024 May;134(5):503-510. doi: 10.1080/00207454.2022.2118599. Epub 2022 Sep 5.
Platelets are crucial players in thrombus formation during ischemic stroke. Platelet (PLT) count and Mean platelet volume (MPV) are important parameters that affect platelet functions. The current study has been carried out with an aim to evaluate the association of MPV and PLT count with ischemic stroke in a population from the Malwa region of Punjab. The study included one hundred and fifty ischemic stroke patients. The extent of disability occurs by stroke was measured by mRS. MPV and PLT was evaluated using cell counter. Further, PLT count was confirmed in 50% of patients using flow cytometer. Clot formation rate was evaluated using Sonoclot Coagulation and Platelet Function Analyzer. All the statistical analysis was carried out using SPSS. A significant association of increased MPV ( < 0.02) was found with the ischemic stroke. However, PLT count did not show a significant association with the disease ( < 0.07). Further, a stepwise multiple logistic regression (MLR) analysis controlling the other confounding risk factors evaluated the association of hypertension and MPV with the disease. Patients with higher mRS were found to have high MPV values confirming that higher MPV is correlated with disability occurs by ischemic stroke. MPV was also found to be significantly associated with large artery atherosclerosis ( < 0.001). Clot formation analysis revealed that ischemic stroke patients bear higher clot rate (CR) and Platelet function (PF) values. Elevated MPV is an independent risk factor for Ischemic stroke along with hypertension. In addition, higher MPV associated significantly with stroke disability as well.
血小板是缺血性中风期间血栓形成的关键因素。血小板（PLT）计数和平均血小板体积（MPV）是影响血小板功能的重要参数。本研究旨在评估旁遮普邦马尔瓦地区人群中MPV和PLT计数与缺血性中风的关联。该研究纳入了150例缺血性中风患者。中风导致的残疾程度通过改良Rankin量表（mRS）进行测量。使用血细胞计数器评估MPV和PLT。此外，50%的患者使用流式细胞仪确认PLT计数。使用Sonoclot凝血和血小板功能分析仪评估血栓形成率。所有统计分析均使用SPSS进行。发现MPV升高（<0.02）与缺血性中风存在显著关联。然而，PLT计数与该疾病未显示出显著关联（<0.07）。此外，控制其他混杂风险因素的逐步多元逻辑回归（MLR）分析评估了高血压和MPV与该疾病的关联。发现mRS较高的患者具有较高的MPV值，证实较高的MPV与缺血性中风导致的残疾相关。还发现MPV与大动脉粥样硬化显著相关（<0.001）。血栓形成分析显示，缺血性中风患者的血栓形成率（CR）和血小板功能（PF）值较高。MPV升高是缺血性中风以及高血压的独立危险因素。此外，较高的MPV也与中风残疾显著相关。
