Şentürk Mustafa, İnce Volkan, Üreyen Orhan, Eyvaz Kemal, Işık Burak, Carr Brian I, Yılmaz Sezai
Department of Surgery, Liver Transplant Institute, İnonu University, Malatya, Türkiye.
Department of General Surgery, İzmir Bozyaka Training and Research Hospital, Health Sciences University, Izmir, Türkiye.
Turk J Gastroenterol. 2025 Jan 6;36(3):169-173. doi: 10.5152/tjg.2025.24540.
BACKGROUND/AIMS: Mean platelet volume (MPV) reflects platelet activation. Platelets have an important role in tumor progression and metastasis. In this study, we wanted to investigate the effect of MPV on survival in patients undergoing liver transplantation (LT) for hepatocellular carcinoma (HCC).
All data of 376 patients who underwent LT and pathologically diagnosed with HCC were analyzed. By determining the cut-off of MPV (10.2 fL), 2 groups with high and low MPV were formed. The groups were compared within themselves. Factors affecting survival were determined by univariate and multivariate analysis.
When the groups were compared, patients with low MPV had significantly higher platelet counts, larger tumor sizes, lower BMI, and higher recurrence rates. In multivariate analysis, GGT >104, AFP >200 μg/L, largest tumor diameter >5 cm, and lower MPV were found to be independent risk factors that affected the prognosis. Tumor-free survival was significantly worse in the lower MPV group (P = .002).
Pre-transplant low MPV may be useful in predicting poor prognosis and a high rate of tumor recurrence in patients with HCC after liver transplantation.
背景/目的：平均血小板体积（MPV）反映血小板活化情况。血小板在肿瘤进展和转移中起重要作用。在本研究中，我们旨在探讨MPV对肝细胞癌（HCC）肝移植（LT）患者生存的影响。
分析376例行LT且经病理诊断为HCC患者的所有数据。通过确定MPV的临界值（10.2 fL），形成高MPV和低MPV两组。组内进行比较。通过单因素和多因素分析确定影响生存的因素。
组间比较时，低MPV患者的血小板计数显著更高、肿瘤体积更大、体重指数更低且复发率更高。多因素分析发现，谷氨酰转肽酶>104、甲胎蛋白>200 μg/L、最大肿瘤直径>5 cm以及较低的MPV是影响预后的独立危险因素。低MPV组的无瘤生存率显著更差（P = 0.002）。
移植前低MPV可能有助于预测HCC患者肝移植后预后不良及高肿瘤复发率。
