银屑病患者自杀风险增加：韩国一项全国性队列研究

Increased risk of suicidality in patients with psoriasis: A Nationwide cohort study in Korea.

作者信息

Kim Sung Min, Ahn Juhee, Cho Young Ah, Sung Jae Young, Kim Chang Yong, Yu Da-Ae, Lee Yang Won, Won Sungho, Choe Yong Beom

机构信息

Department of Dermatology, Konkuk University School of Medicine, Seoul, Republic of Korea.

Department of Public Health Sciences, Seoul National University, Seoul, Republic of Korea.

出版信息

J Eur Acad Dermatol Venereol. 2023 Jan;37(1):75-84. doi: 10.1111/jdv.18565. Epub 2022 Sep 24.

DOI:10.1111/jdv.18565

PMID:36028994

Abstract

BACKGROUND

Psoriasis has a devastating psychological impact on patients' quality of life. However, the relationship between suicidality and psoriasis remains unclear.

OBJECTIVE

This study analysed and compared the risk of suicidality (suicidal ideation, suicide attempt and completed suicide) between patients with psoriasis and the general population.

METHODS

This nationwide, population-based, retrospective, cohort study analysed the Korean National Health Insurance Service claim data from 2005 to 2018.

RESULTS

The study included 348,439 patients with psoriasis aged over 18 years and with age- and sex-matched controls. The risk of suicidality was higher in the psoriasis group than in the control group [adjusted hazard ratio (aHR) 1.21; 95% confidence interval (CI), 1.18-1.24]. The aHR of suicidality was higher in the psoriatic arthritis group (aHR, 1.46; 95% CI, 1.39-1.54) than in the psoriasis-alone group (aHR, 1.17; 95% CI, 1.13-1.20). However, the severity of psoriasis and suicidality showed no correlation (mild psoriasis group: aHR, 1.22; 95% CI, 1.18-1.25; moderate-to-severe psoriasis group: aHR, 1.16; 95% CI, 1.10-1.23).

CONCLUSION

Patients with psoriasis have an increased risk of suicidality. In particular, the presence of arthritis in patients had a more significant effect on the risk of suicidality.

摘要

背景

银屑病对患者的生活质量有严重的心理影响。然而，自杀倾向与银屑病之间的关系仍不明确。

目的

本研究分析并比较了银屑病患者与普通人群的自杀倾向（自杀意念、自杀未遂和自杀死亡）风险。

方法

这项基于全国人口的回顾性队列研究分析了2005年至2018年韩国国民健康保险服务的理赔数据。

结果

该研究纳入了348439名年龄在18岁以上的银屑病患者，并设有年龄和性别匹配的对照组。银屑病组的自杀倾向风险高于对照组[调整后风险比（aHR）为1.21；95%置信区间（CI）为1.18 - 1.24]。银屑病关节炎组的自杀倾向aHR（1.46；95% CI为1.39 - 1.54）高于单纯银屑病组（aHR为1.17；95% CI为1.13 - 1.20）。然而，银屑病的严重程度与自杀倾向之间没有相关性（轻度银屑病组：aHR为1.22；95% CI为1.18 - 1.25；中度至重度银屑病组：aHR为1.16；95% CI为1.10 - 1.23）。