Department of Gastroenterology and Inserm NGERE U1256, Nancy University Hospital, University of Lorraine, Nancy, France.
Department of Medicine, Western University, London, Ontario, Canada.
United European Gastroenterol J. 2022 Oct;10(8):854-867. doi: 10.1002/ueg2.12283. Epub 2022 Aug 27.
We performed a systematic review to investigate the definition of mild to moderate active ulcerative colitis (UC), and to describe predictors of good response to treatment in clinical trials assessing 5-ASA and/or budesonide. Thirty-nine randomized controlled trials were included. The UC Disease Activity Index (UCDAI) was the most frequent score used for defining mild to moderate active UC (16 studies, 41%), followed by Clinical Activity Index in 11 studies (28.2%). Four different cut-offs were used to define mild to moderate active UC using the UCDAI. The most frequently reported predictors of good response to treatment was a mild and moderate disease activity. There is heterogeneity in the definition of mild to moderate active UC in randomized clinical trials. A standardized definition of mild to moderate active UC used for inclusion of patients in clinical trials is needed.
我们进行了一项系统评价，旨在研究轻度至中度活动溃疡性结肠炎（UC）的定义，并描述在评估 5-ASA 和/或布地奈德的临床试验中，预测治疗良好反应的指标。共纳入 39 项随机对照试验。最常使用的用于定义轻度至中度活动 UC 的评分是 UC 疾病活动指数（UCDAI）（16 项研究，41%），其次是临床活动指数（11 项研究，28.2%）。使用 UCDAI 定义轻度至中度活动 UC 时，使用了 4 种不同的截断值。报道最多的治疗良好反应的预测指标是疾病活动轻中度。随机临床试验中对轻度至中度活动 UC 的定义存在异质性。需要为临床试验中患者的纳入制定一个标准化的轻度至中度活动 UC 的定义。
